{"id":"W2072066573","doi":"10.1371/journal.pntd.0001512","title":"Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing","year":2012,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Compute Canada","keywords":"Biology; Miltefosine; Population; Genetics; Gene; Leishmania; Mutant; Leishmaniasis; Visceral leishmaniasis; Parasite hosting; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000009414434,0.0003117125,0.0005312657,0.0002836502,0.0002215171,0.00006094707,0.0001503471,0.0001111797,0.0001837309],"category_scores_gemma":[0.002029176,0.0002798195,0.0001615624,0.0005324007,0.0001230462,0.0002968252,0.00009581284,0.0002617485,0.0001436253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007119962,"about_ca_system_score_gemma":0.0001164485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005209853,"about_ca_topic_score_gemma":0.0002744459,"domain_scores_codex":[0.9972631,0.000208338,0.0005400654,0.0004477726,0.0006695883,0.0008711458],"domain_scores_gemma":[0.9984123,0.0002992209,0.0001007949,0.0003830685,0.0001715598,0.000633079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006107368,0.001105716,0.366889,0.0001749165,0.0001704858,0.0001614167,0.0001862455,0.00002363077,0.6301414,0.0000179566,0.000210668,0.000307763],"study_design_scores_gemma":[0.002148655,0.0003579773,0.9909257,0.0001324775,0.0002567056,0.00002951892,0.0001025167,0.001006187,0.004388172,0.00007588076,0.0003010292,0.0002751721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944109,0.003275076,0.00004665856,0.0006220916,0.0000526785,0.000993274,0.0002778593,0.0002142439,0.0001072564],"genre_scores_gemma":[0.9975712,0.00005696414,0.0004160781,0.0002815126,0.0002311414,0.0002941235,0.0008768716,0.0000660956,0.0002059604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6257533,"threshold_uncertainty_score":0.9999654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565272174014503,"score_gpt":0.2806021334387843,"score_spread":0.2549494116986392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}