{"id":"W2072079965","doi":"10.1111/eva.12030","title":"An evolutionary explanation for the presence of cancer nonstem cells in neoplasms","year":2012,"lang":"en","type":"article","venue":"Evolutionary Applications","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"National Cancer Institute; National Human Genome Research Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; American Cancer Society","keywords":"Biology; Multicellular organism; Cancer stem cell; Cancer cell; Cancer; Stem cell; Somatic evolution in cancer; Evolutionary dynamics; Evolutionary biology; Cell; Genetics; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007353503,0.0001927824,0.0003058708,0.0004976557,0.0008153159,0.0008961094,0.0008850693,0.001084715,0.0021009],"category_scores_gemma":[0.002741569,0.0002218727,0.0004860937,0.0003422502,0.001577309,0.001888691,0.0008968628,0.0006281545,0.0001355874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007015952,"about_ca_system_score_gemma":0.0004560183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009536321,"about_ca_topic_score_gemma":0.001344155,"domain_scores_codex":[0.9998437,0.00004951463,0.000006133528,0.00004525054,0.00002981247,0.0000256424],"domain_scores_gemma":[0.9991207,0.0005119902,0.0001109958,0.00007346684,0.00007830543,0.0001046356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001648645,0.00008681163,0.02802384,0.0001980743,0.00005928287,0.001704235,0.001176753,0.3228379,0.03406708,0.5848314,0.00128841,0.02556138],"study_design_scores_gemma":[0.00006071235,0.00009726569,0.01041755,0.00002575835,0.00004566527,0.0009060003,0.0005152117,0.7122949,0.006010205,0.2655828,0.003990166,0.00005366458],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8640658,0.0005151324,0.1197355,0.004017597,0.00006499366,0.00002371388,0.00007892228,0.0001026704,0.01139576],"genre_scores_gemma":[0.9869589,0.0001615025,0.01158714,0.0001277595,0.00001374182,0.00001659443,0.00002319127,0.00001256226,0.001098633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0021009,"threshold_uncertainty_score":0.007028282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267531378060556,"score_gpt":0.3190997924999763,"score_spread":0.2964244787193707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}