{"id":"W2072103143","doi":"10.1089/scd.2011.0297","title":"Cationic Liposome-Mediated <i>CXCR4</i> Gene Delivery into Hematopoietic Stem/Progenitor Cells: Implications for Clinical Transplantation and Gene Therapy","year":2011,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; National Institute for Nanotechnology; Alberta Cancer Foundation; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Blood Services; California HIV/AIDS Research Program","keywords":"Biology; CXCR4; Transfection; Haematopoiesis; Progenitor cell; Genetic enhancement; Gene delivery; CXC chemokine receptors; CD34; Stem cell; Chemokine receptor; Transplantation; Homing (biology); Cancer research; Immunology; Cell biology; Molecular biology; Chemokine; Cell culture; Immune system; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004089816,0.0001921425,0.0001892548,0.00005293598,0.0002228084,0.00003342103,0.0001526451,0.0001639047,0.000008547946],"category_scores_gemma":[0.000001490311,0.000176133,0.00005423357,0.00007353187,0.00009248088,0.000008159896,0.00004612146,0.00006649818,0.00001142521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002068817,"about_ca_system_score_gemma":0.0002881918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001019195,"about_ca_topic_score_gemma":0.00006609909,"domain_scores_codex":[0.9986108,0.00008342798,0.0004290279,0.0004939029,0.0001134644,0.0002693832],"domain_scores_gemma":[0.9992557,0.00004617793,0.0001010926,0.0002578683,0.0001593296,0.0001798446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009310553,0.0001498322,0.002379785,0.00008762087,0.0001425463,0.000001223217,0.001020958,0.000001477362,0.9516637,0.000006663821,0.0001812364,0.04343384],"study_design_scores_gemma":[0.001440609,0.0008160772,0.002793564,0.000008874167,0.00001699405,0.000009833922,0.00009624653,0.000008059154,0.989195,0.00003507948,0.005337863,0.0002417291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908413,0.00607212,0.00199723,0.00006704069,0.0001268229,0.0007915525,0.00005912854,0.00001761116,0.00002716485],"genre_scores_gemma":[0.9614292,0.02991034,0.007364759,0.0003128124,0.0001101799,0.000387128,0.0002480126,0.00004369252,0.0001938106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04319211,"threshold_uncertainty_score":0.7182496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05716036944649776,"score_gpt":0.3080731363952407,"score_spread":0.2509127669487429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}