{"id":"W2072103143","doi":"10.1089/scd.2011.0297","title":"Cationic Liposome-Mediated <i>CXCR4</i> Gene Delivery into Hematopoietic Stem/Progenitor Cells: Implications for Clinical Transplantation and Gene Therapy","year":2011,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; National Institute for Nanotechnology; Alberta Cancer Foundation; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Blood Services; California HIV/AIDS Research Program","keywords":"Biology; CXCR4; Transfection; Haematopoiesis; Progenitor cell; Genetic enhancement; Gene delivery; CXC chemokine receptors; CD34; Stem cell; Chemokine receptor; Transplantation; Homing (biology); Cancer research; Immunology; Cell biology; Molecular biology; Chemokine; Cell culture; Immune system; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004276604,0.0003758834,0.000290873,0.0002074125,0.000106641,0.000462537,0.0002302956,0.0005037798,0.0007440531],"category_scores_gemma":[0.0001995021,0.0001228573,0.0002266184,0.0001653249,0.0003365128,0.0004606406,0.000209131,0.0003965622,0.0002592485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005723122,"about_ca_system_score_gemma":0.0003163141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005814512,"about_ca_topic_score_gemma":0.0003861571,"domain_scores_codex":[0.9998698,0.00003887321,0.00000965019,0.00001904005,0.00002794151,0.00003467076],"domain_scores_gemma":[0.9999197,0.00001665255,0.00003135256,0.000004194673,0.0000169628,0.00001120101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000137191,0.00006599011,0.0003089049,0.0002210914,0.000007693926,0.00008195091,0.00002927193,0.0004376607,0.987537,0.0004611553,0.0001516273,0.01056057],"study_design_scores_gemma":[0.00005139184,0.0009949841,0.001625321,0.0000396021,0.0000525028,0.0004934433,0.00004588053,0.002741971,0.987173,0.0002119197,0.006550514,0.0000194575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9117961,0.0392396,0.04348917,0.001606722,0.00009659467,0.0002770783,0.000296534,0.0003079215,0.002890344],"genre_scores_gemma":[0.9670182,0.01532779,0.01501694,0.0002948995,0.00003036202,0.0001145221,0.0002711371,0.00004574483,0.001880446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007440531,"threshold_uncertainty_score":0.004152417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05716036944649776,"score_gpt":0.3080731363952407,"score_spread":0.2509127669487429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}