{"id":"W2072127867","doi":"10.1016/j.bmc.2005.02.020","title":"Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"Kuwait University","keywords":"Chemistry; Sulfone; Piperacillin; Hydrazone; Klebsiella pneumoniae; Ceftazidime; Oxime; Enzyme; Stereochemistry; Lactam; Antibacterial agent; Beta-Lactamase Inhibitors; Enzyme inhibitor; Pseudomonas aeruginosa; Escherichia coli; Chemical synthesis; Tazobactam; Biochemistry; Bacteria; Antibiotics; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002986125,0.0003964618,0.0002821683,0.0002740392,0.0001768454,0.0002468821,0.0002831592,0.0002096317,0.001977948],"category_scores_gemma":[0.0002547765,0.0001220824,0.0001903238,0.0002122263,0.0001921857,0.0002195538,0.0001655662,0.0003125288,0.0002542667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002405043,"about_ca_system_score_gemma":0.0002278216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005015141,"about_ca_topic_score_gemma":0.0007458502,"domain_scores_codex":[0.9998909,0.00003030349,0.00001159349,0.00001116553,0.00002760085,0.00002842457],"domain_scores_gemma":[0.9999191,0.00001961056,0.00001440299,0.000008964286,0.00001390386,0.00002403809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001233642,0.0003317993,0.0004426744,0.0003195563,0.00003649964,0.0006661447,0.00009260757,0.002294772,0.9700437,0.0009697539,0.0003616503,0.02320726],"study_design_scores_gemma":[0.0001571021,0.003386644,0.001060087,0.00001667109,0.00003415911,0.0003213972,0.00002957127,0.000892079,0.9866834,0.00007831732,0.007331205,0.000009343737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819496,0.008012012,0.002820868,0.0001573124,0.00008604553,0.000116902,0.0004239247,0.00008381471,0.006349381],"genre_scores_gemma":[0.9897077,0.004588972,0.00193449,0.00005016058,0.00002439193,0.00003082753,0.0004086772,0.00001184644,0.003242983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001977948,"threshold_uncertainty_score":0.00661689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01947146454522695,"score_gpt":0.275098556965138,"score_spread":0.2556270924199111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}