{"id":"W2072138658","doi":"10.1016/j.neuron.2007.03.027","title":"Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome","year":2007,"lang":"en","type":"article","venue":"Neuron","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Neurogenesis; Neural stem cell; Protein tyrosine phosphatase; Neuroscience; Cell fate determination; Biology; Gene knockdown; Hippocampal formation; Gliogenesis; Cell biology; Stem cell; Signal transduction; Cell culture; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289137,0.00008109602,0.00009831114,0.00003621892,0.00001964783,0.000005119827,0.00007630536,0.0000702808,0.000004641576],"category_scores_gemma":[0.0001005738,0.00008195289,0.00002097801,0.00006285647,0.00002556185,0.000003978267,0.00004313573,0.0000446221,0.000002017915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005527518,"about_ca_system_score_gemma":0.00001355672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001884221,"about_ca_topic_score_gemma":0.00002104839,"domain_scores_codex":[0.9993804,0.00002470218,0.0001724829,0.000195218,0.00008284813,0.0001443876],"domain_scores_gemma":[0.9996817,0.00003292397,0.00006204239,0.0001502327,0.00002613147,0.00004699001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008792317,0.00004862095,0.002470053,0.000008618625,0.000002839264,0.000009214579,0.000004779185,0.00002842352,0.9954922,0.0001407223,0.0002797236,0.00142684],"study_design_scores_gemma":[0.0008677654,0.0002774119,0.0700513,0.00001233036,0.000006359139,0.00001358849,0.000002846463,0.00009480857,0.9266405,0.00004520409,0.001908625,0.00007932824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932777,0.005029348,0.001216018,0.00006718779,0.00004270465,0.0001941164,0.00007181006,0.000004441863,0.00009669238],"genre_scores_gemma":[0.9995339,0.0001069739,0.00008674621,0.0001126543,0.0000133663,0.000005184103,0.00006787397,0.00001152141,0.00006180933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06885181,"threshold_uncertainty_score":0.3341942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006533511076236989,"score_gpt":0.2287870665889857,"score_spread":0.2222535555127487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}