{"id":"W2072152122","doi":"10.1038/sj.onc.1207940","title":"Genetic programs regulating HSC specification, maintenance and expansion","year":2004,"lang":"en","type":"review","venue":"Oncogene","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Biology; Stem cell; Haematopoiesis; Induced pluripotent stem cell; Chromatin; Cell biology; Population; Immunology; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002013104,0.0003525208,0.0005412959,0.00006297029,0.0001038691,0.00005346374,0.000187311,0.000413497,0.000008891318],"category_scores_gemma":[0.00005443189,0.0003095272,0.0001933051,0.0001532573,0.00008531888,0.000002234057,0.0001253746,0.0001238716,0.00001677657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005408171,"about_ca_system_score_gemma":0.0002310966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001055042,"about_ca_topic_score_gemma":0.00001258466,"domain_scores_codex":[0.9982606,0.0000924548,0.000519921,0.0006817806,0.000160834,0.0002844483],"domain_scores_gemma":[0.9988346,0.00001133871,0.0003511186,0.0005827235,0.0001028415,0.0001174146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003313043,0.00003150884,0.0000206288,0.001622746,0.00003875808,0.000002802706,0.00001188603,0.000008295415,0.004052831,0.00003369296,0.0000280165,0.9941455],"study_design_scores_gemma":[0.000209213,0.0001595554,0.00004374559,0.002464981,0.0001493421,0.00003233842,0.000007331992,0.000004452128,0.001461906,0.0001730385,0.9949044,0.0003897218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001628596,0.9951596,0.001889545,0.00001168738,0.0001534288,0.0006464036,0.00001404121,0.0000174324,0.0004792298],"genre_scores_gemma":[0.00086327,0.9881727,0.008992176,0.000009814047,0.0005335188,0.0001021189,0.000544028,0.00008082596,0.0007015428],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9948764,"threshold_uncertainty_score":0.9999357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03630339901445875,"score_gpt":0.3100569183328869,"score_spread":0.2737535193184282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}