{"id":"W2072181397","doi":"10.1016/j.cmet.2012.07.016","title":"Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae","year":2012,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; Lipid metabolism; AMP-activated protein kinase; Biology; Caenorhabditis elegans; Protein kinase A; Autophagy; Hydrogen peroxide; Mitochondrion; Biochemistry; Beta oxidation; Metabolism; Chemistry; Kinase; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007045735,0.0003124553,0.000578706,0.0001723085,0.00004907476,0.00001313337,0.00046031,0.0003097533,0.00007370063],"category_scores_gemma":[0.00008901705,0.0003178626,0.0001798285,0.0002029821,0.0001350547,0.0000209289,0.0001638508,0.0001967933,0.00001484839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001695396,"about_ca_system_score_gemma":0.000119928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003306478,"about_ca_topic_score_gemma":0.00003253751,"domain_scores_codex":[0.9978029,0.0002670097,0.0006748048,0.0004256817,0.0003390358,0.0004905789],"domain_scores_gemma":[0.9984777,0.00002255093,0.0003842415,0.0007425334,0.0001784361,0.0001945178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005279728,0.0004693867,0.002300134,0.00006818093,0.00006213609,4.964974e-7,0.001253808,0.0003051079,0.9948651,0.0001914183,0.00005587715,0.0003755862],"study_design_scores_gemma":[0.00151282,0.0000286257,0.06049982,0.00001046913,0.0001293367,0.000003790105,0.0001652683,0.00009578751,0.9329137,0.00008740144,0.004258421,0.0002945544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906695,0.005869547,0.001941277,0.00004063407,0.0003242999,0.0004416089,0.0001105913,0.00001332684,0.0005892278],"genre_scores_gemma":[0.99637,0.0003629727,0.00228348,0.0001174723,0.0004035813,0.00003300425,0.00009499336,0.00005709062,0.0002773593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06195136,"threshold_uncertainty_score":0.9999273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194833144016712,"score_gpt":0.2440028438360808,"score_spread":0.2220545123959137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}