{"id":"W2072181858","doi":"10.1016/j.bcp.2014.06.014","title":"Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment","year":2014,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Nature Conservancy of Canada; European Commission","keywords":"Internal medicine; Endocrinology; Insulin resistance; Insulin; Insulin receptor; Gluconeogenesis; Biology; Glucokinase; Glucose uptake; Carbohydrate metabolism; Metabolism; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001023819,0.0001760641,0.0004873998,0.00009642312,0.00001429459,0.000002897619,0.00005435495,0.0001281371,0.001807064],"category_scores_gemma":[0.00005040495,0.0001425383,0.0001010871,0.0001466566,0.00012435,0.00002449136,0.00002508078,0.0000825809,0.00002672046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337078,"about_ca_system_score_gemma":0.00006032096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008154819,"about_ca_topic_score_gemma":8.790536e-7,"domain_scores_codex":[0.9989543,0.0000660067,0.0003414738,0.0002709752,0.000096819,0.0002704196],"domain_scores_gemma":[0.9994597,0.0001445808,0.00007488074,0.0001185737,0.00004942471,0.0001527971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130149,0.0004703596,0.009461151,0.00008644818,0.00009157212,0.00001620763,0.0001614928,0.00001116123,0.9861448,0.000003255633,0.001091292,0.001160742],"study_design_scores_gemma":[0.004049076,0.001134418,0.006170655,0.00003675967,0.000164635,0.000009779963,0.00003945155,0.0004653645,0.9813039,0.00002436438,0.006472156,0.0001294919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944034,0.0039215,0.00001428596,0.0003660494,0.0002044029,0.0002443394,0.000008521099,0.00004094061,0.0007965142],"genre_scores_gemma":[0.9977592,0.0002711307,0.0006005003,0.0005847361,0.0003792854,0.0001197678,0.00002553163,0.00001570943,0.000244167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005380864,"threshold_uncertainty_score":0.9991054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289344856388069,"score_gpt":0.2838294896114671,"score_spread":0.2709360410475864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}