{"id":"W2072238337","doi":"10.1038/sj.gt.3302394","title":"Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase","year":2004,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Thymidine kinase; Herpes simplex virus; Biology; Ganciclovir; Green fluorescent protein; Cell culture; Suicide gene; Transduction (biophysics); Bystander effect; Western blot; Intracellular; Virology; Molecular biology; Transfection; Virus; Cell biology; Genetic enhancement; Gene; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009536436,0.0002189979,0.0002583146,0.00006477526,0.0001411566,0.00002475389,0.0009879918,0.00008133145,0.00005764048],"category_scores_gemma":[0.0002113645,0.0001243393,0.0001905998,0.0003478901,0.0001293721,0.000005558159,0.0001233505,0.00006805411,0.000005748937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003024757,"about_ca_system_score_gemma":0.0002095305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621346,"about_ca_topic_score_gemma":0.0009666202,"domain_scores_codex":[0.998437,0.0001348644,0.0003451745,0.0004011355,0.0003006907,0.0003811562],"domain_scores_gemma":[0.9984304,0.0001992992,0.0001144021,0.0009506543,0.0002086125,0.00009665272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009295373,0.00009662075,0.00001007696,0.00001607508,0.0001255695,0.000001377385,0.0008294847,0.007552776,0.8965305,0.000006592104,0.0002739237,0.0852616],"study_design_scores_gemma":[0.0009323169,0.00497528,0.0001557571,0.00005340123,0.00001024677,0.000002426455,0.0001567461,0.00004950129,0.9720605,0.00002573296,0.02141675,0.0001613361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811755,0.006668279,0.008741664,0.001816872,0.0001018534,0.001389815,0.00008173758,0.00001312838,0.00001111361],"genre_scores_gemma":[0.9946902,0.002801774,0.0006430341,0.001208446,0.0002428241,0.0002059393,0.00001161162,0.0000463981,0.000149809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08510026,"threshold_uncertainty_score":0.5070412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08108547277799955,"score_gpt":0.3633732954227377,"score_spread":0.2822878226447382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}