{"id":"W2072238337","doi":"10.1038/sj.gt.3302394","title":"Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase","year":2004,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Université Laval; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Thymidine kinase; Herpes simplex virus; Biology; Ganciclovir; Green fluorescent protein; Cell culture; Suicide gene; Transduction (biophysics); Bystander effect; Western blot; Intracellular; Virology; Molecular biology; Transfection; Virus; Cell biology; Genetic enhancement; Gene; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654626,0.0004767192,0.0002956627,0.0002847234,0.0004550569,0.0009279873,0.0003832357,0.0007662621,0.002006989],"category_scores_gemma":[0.0005777825,0.0002024915,0.0002462216,0.0002742514,0.0006149354,0.0006236311,0.000603632,0.001079926,0.001022911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003760863,"about_ca_system_score_gemma":0.000475192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007570357,"about_ca_topic_score_gemma":0.0005329783,"domain_scores_codex":[0.9998029,0.00002379278,0.0000142909,0.00004456996,0.00006760327,0.00004687134],"domain_scores_gemma":[0.9993311,0.0002449654,0.00008724186,0.0001404683,0.00009770001,0.00009857762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003896696,0.00000880919,0.0001307625,0.00002825586,0.000004070624,0.0001122978,0.00002172301,0.00002341783,0.9980738,0.0008950284,0.00004262864,0.0006201526],"study_design_scores_gemma":[0.00001002956,0.00003962127,0.002079488,0.000007011534,0.00001776819,0.00129676,0.00005795454,0.0005077916,0.9927558,0.0003011812,0.002922306,0.000004258173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582115,0.002628779,0.02496694,0.0003511261,0.0001292588,0.00003303232,0.000628814,0.0002906593,0.01275985],"genre_scores_gemma":[0.9881356,0.001017211,0.005126738,0.00009615371,0.00001642732,0.00004683187,0.001090071,0.0001167628,0.004354128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006989,"threshold_uncertainty_score":0.006713986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08108547277799955,"score_gpt":0.3633732954227377,"score_spread":0.2822878226447382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}