{"id":"W2072242965","doi":"10.1128/jvi.01466-09","title":"Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4 <sup>+</sup> T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transgene; Genetically modified mouse; Haematopoiesis; Phenotype; T cell; Virology; Immunodeficiency; Apoptosis; Effector; Immunology; Molecular biology; Cancer research; Immune system; Cell biology; Stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000287517,0.0009144743,0.0003107201,0.0008521362,0.0003342298,0.0004262855,0.0004094976,0.000799352,0.002125242],"category_scores_gemma":[0.00008492053,0.0003314366,0.0003219567,0.0002661305,0.0004519756,0.0004199278,0.0002386304,0.001327737,0.0007419427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523125,"about_ca_system_score_gemma":0.0002475669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003102536,"about_ca_topic_score_gemma":0.0005951443,"domain_scores_codex":[0.999819,0.00003325112,0.00002483563,0.00004845692,0.00003950005,0.00003504363],"domain_scores_gemma":[0.9998584,0.00001389298,0.00003729412,0.00001983624,0.00001322723,0.00005727718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002588931,0.0002893786,0.0002582736,0.00005858245,0.000008158456,0.0004173289,0.00004315008,0.00007480015,0.9960015,0.0006517221,0.0001826792,0.001755548],"study_design_scores_gemma":[0.00036092,0.003190813,0.006278358,0.00005419449,0.000080335,0.008673522,0.00007643143,0.002908349,0.9563641,0.0005629789,0.02142214,0.00002780482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781537,0.00125718,0.01348734,0.0003382828,0.0001117904,0.0003230732,0.001723313,0.0005912233,0.004014062],"genre_scores_gemma":[0.9557918,0.001848391,0.01800874,0.0002556155,0.00006657697,0.0006287558,0.002796235,0.0001415559,0.0204624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125242,"threshold_uncertainty_score":0.007109642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847597093715226,"score_gpt":0.2679163508955903,"score_spread":0.249440379958438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}