{"id":"W2072243112","doi":"10.1242/dev.01573","title":"Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription","year":2004,"lang":"en","type":"article","venue":"Development","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; TCF4; SMAD; Transcription factor; Transcription (linguistics); Beta-catenin; Cancer research; Chromatin immunoprecipitation; Molecular biology; Cell biology; Promoter; Gene; Signal transduction; Genetics; Wnt signaling pathway; Gene expression; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310196,0.000122711,0.0001233574,0.00004043096,0.00004577317,0.00002395232,0.00005380408,0.00007717724,0.000002313445],"category_scores_gemma":[0.000006098488,0.00007959561,0.00000837664,0.0001011567,0.00004326803,0.000003062688,0.00001961532,0.00008993835,0.000002390539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004969345,"about_ca_system_score_gemma":0.00009551771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004899952,"about_ca_topic_score_gemma":0.0005771389,"domain_scores_codex":[0.9993048,0.00003697303,0.0001448577,0.0002336263,0.00008731165,0.0001923994],"domain_scores_gemma":[0.9998295,0.000003525906,0.00002724257,0.00005546763,0.00002733973,0.00005692167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532891,0.00003308451,0.0005081621,0.0000159318,0.00006589975,0.00004433448,0.001107509,0.002511543,0.992065,0.00002485116,0.00004040908,0.003330058],"study_design_scores_gemma":[0.01013633,0.0009370624,0.1603589,0.0003331156,0.00004568289,0.00009980642,0.0002062071,0.0001470249,0.8101888,0.00006827879,0.01682057,0.0006582763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994845,0.0003402592,0.002783649,0.00157398,0.00001884424,0.000347971,0.000003659811,0.000003758108,0.00008293144],"genre_scores_gemma":[0.9983681,0.00005512259,0.0007439475,0.0006065222,0.000009590232,0.00006496567,0.00002396154,0.00001034609,0.0001174159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818762,"threshold_uncertainty_score":0.3245814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004923188771183996,"score_gpt":0.2025958303393333,"score_spread":0.1976726415681493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}