{"id":"W2072243112","doi":"10.1242/dev.01573","title":"Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription","year":2004,"lang":"en","type":"article","venue":"Development","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; TCF4; SMAD; Transcription factor; Transcription (linguistics); Beta-catenin; Cancer research; Chromatin immunoprecipitation; Molecular biology; Cell biology; Promoter; Gene; Signal transduction; Genetics; Wnt signaling pathway; Gene expression; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194396,0.0003084886,0.0001722761,0.0003338003,0.0002379461,0.0002520603,0.0001766006,0.0002018406,0.00119241],"category_scores_gemma":[0.000181375,0.0003377345,0.0002679594,0.0001319413,0.0002597396,0.0001213496,0.0002338741,0.0003248847,0.0005444885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005294626,"about_ca_system_score_gemma":0.000189833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006457077,"about_ca_topic_score_gemma":0.001491329,"domain_scores_codex":[0.9998073,0.00002494986,0.0000104086,0.00006681163,0.00006061581,0.00002998272],"domain_scores_gemma":[0.9997941,0.00003369981,0.00007269307,0.00002063022,0.00001759713,0.00006129373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003039048,0.000003578475,0.0004091294,0.000009186309,0.000003510674,0.00003015723,0.000008527769,0.00001556157,0.9992138,0.00003242932,0.000006057026,0.0002377523],"study_design_scores_gemma":[0.00001086487,0.00008391543,0.02442041,0.000006597307,0.00001730839,0.0006266864,0.0000410103,0.001085775,0.9721152,0.0001032237,0.001484356,0.000004659659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949999,0.0008781495,0.003515643,0.00003405743,0.000007869485,0.000008518108,0.0001110427,0.00005445081,0.0003904286],"genre_scores_gemma":[0.9953439,0.0002313524,0.002187815,0.0000269811,0.000004143091,0.0000159322,0.0004656797,0.00001971029,0.001704473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119241,"threshold_uncertainty_score":0.003989041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004923188771183996,"score_gpt":0.2025958303393333,"score_spread":0.1976726415681493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}