{"id":"W2072257654","doi":"10.1002/glia.21001","title":"Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann‐Pick type C1‐deficient mouse brains","year":2010,"lang":"en","type":"article","venue":"Glia","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; National Institute on Aging; Ara Parseghian Medical Research Foundation; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"NPC1; Cerebellum; Amyloid precursor protein; Hippocampus; Amyloid precursor protein secretase; Biology; Niemann–Pick disease; Alzheimer's disease; Niemann–Pick disease, type C; BACE1-AS; Protein precursor; Neuroscience; Endocrinology; Internal medicine; Intracellular; Cell biology; Enzyme; Biochemistry; Cholesterol; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728173,0.0008231249,0.0005895442,0.001793096,0.000293632,0.0005643158,0.0003591255,0.0008685705,0.001198323],"category_scores_gemma":[0.0001790044,0.0005930185,0.0005705756,0.0004441801,0.0004572919,0.0006033513,0.000353856,0.0009776424,0.0004532345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004289978,"about_ca_system_score_gemma":0.0002183024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212482,"about_ca_topic_score_gemma":0.001345771,"domain_scores_codex":[0.9997181,0.00001847699,0.00004702828,0.00008443119,0.00007457433,0.00005731565],"domain_scores_gemma":[0.9995852,0.00002760376,0.0001801329,0.00002891175,0.00003853611,0.0001396676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002150404,0.00004536709,0.0004746188,0.00003168611,0.00001506731,0.0001939309,0.00005691768,0.00003830285,0.9982567,0.00005883348,0.0000213124,0.000592049],"study_design_scores_gemma":[0.00005771103,0.0007460006,0.06189481,0.00002706531,0.0001111905,0.002506672,0.0001924749,0.0008443021,0.9313677,0.0003100854,0.001896834,0.00004514235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938794,0.002334275,0.001630422,0.00006194539,0.00002724816,0.00003357074,0.001049071,0.000159671,0.0008243019],"genre_scores_gemma":[0.9871977,0.002803054,0.003707066,0.0001071642,0.00001740825,0.0001186749,0.001357848,0.0001468347,0.004544206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793096,"threshold_uncertainty_score":0.00400877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02821739971803784,"score_gpt":0.3065333120380773,"score_spread":0.2783159123200394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}