{"id":"W2072257654","doi":"10.1002/glia.21001","title":"Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann‐Pick type C1‐deficient mouse brains","year":2010,"lang":"en","type":"article","venue":"Glia","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; National Institute on Aging; Ara Parseghian Medical Research Foundation; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"NPC1; Cerebellum; Amyloid precursor protein; Hippocampus; Amyloid precursor protein secretase; Biology; Niemann–Pick disease; Alzheimer's disease; Niemann–Pick disease, type C; BACE1-AS; Protein precursor; Neuroscience; Endocrinology; Internal medicine; Intracellular; Cell biology; Enzyme; Biochemistry; Cholesterol; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211373,0.0001063645,0.0002060021,0.00007969012,0.0000472249,0.00002384388,0.00005991745,0.00009634659,0.00003427169],"category_scores_gemma":[0.0005453522,0.00009094202,0.00001651306,0.0002284708,0.0001003982,0.0001011363,0.00006641112,0.0002532983,0.00000574893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003280534,"about_ca_system_score_gemma":0.000108507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007238911,"about_ca_topic_score_gemma":0.0001225573,"domain_scores_codex":[0.9990583,0.00003093016,0.0001917303,0.0002386709,0.0002443901,0.0002359711],"domain_scores_gemma":[0.9995189,0.0000180765,0.00006110296,0.0001347134,0.0001651061,0.0001020602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004243192,0.0003736438,0.0317266,0.001035012,0.00001794272,0.0000187966,0.001599236,0.000001496118,0.9531364,0.0008356574,0.000266938,0.01056399],"study_design_scores_gemma":[0.00393392,0.0007898948,0.3889384,0.000431399,0.00003144558,0.00004866148,0.0003996597,0.00267387,0.6005002,0.0003020262,0.001652866,0.0002976793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970734,0.001382998,0.00002957431,0.0004945483,0.00003266312,0.0007851825,0.0000456446,0.00002138218,0.0001346776],"genre_scores_gemma":[0.9989094,0.0000120855,0.0001231378,0.00002006565,0.00003323584,0.00002709837,0.00003387314,0.00001367454,0.0008274954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3572118,"threshold_uncertainty_score":0.3708508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02821739971803784,"score_gpt":0.3065333120380773,"score_spread":0.2783159123200394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}