{"id":"W2072271141","doi":"10.1016/j.reprotox.2014.12.005","title":"In utero exposure to the endocrine disruptor di(2-ethylhexyl) phthalate targets ovarian theca cells and steroidogenesis in the adult female rat","year":2014,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; F. Hoffmann-La Roche","keywords":"Phthalate; Endocrinology; Endocrine disruptor; Internal medicine; In utero; Anogenital distance; Offspring; Estrous cycle; Theca; Litter; Endocrine system; Andrology; Biology; Ovary; Chemistry; Pregnancy; Hormone; Medicine; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008727192,0.0003180341,0.0002269819,0.0004373517,0.0002624377,0.0004635478,0.0002253059,0.0002911254,0.002845636],"category_scores_gemma":[0.0001430432,0.0003479852,0.0002506098,0.0002061171,0.0004910766,0.0004293804,0.000245246,0.0004659211,0.0004383581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649006,"about_ca_system_score_gemma":0.0004235404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003770709,"about_ca_topic_score_gemma":0.008596406,"domain_scores_codex":[0.9998945,0.000008845871,0.000003466995,0.00002693197,0.00002524551,0.0000409559],"domain_scores_gemma":[0.9998926,0.00001404876,0.00002963822,0.00001197671,0.00001465752,0.00003707528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005534312,0.00005253088,0.003594556,0.0000263803,0.00001410756,0.0001567127,0.00006647209,0.00006236442,0.9917538,0.0002093346,0.0001510119,0.003359242],"study_design_scores_gemma":[0.00003337101,0.000690499,0.0730703,0.00001272677,0.00005604764,0.0004942423,0.0004296034,0.0002291718,0.9209728,0.0002248258,0.003775863,0.00001054495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943258,0.001395231,0.001345344,0.0001930858,0.00006039339,0.00001191972,0.000489224,0.00004658475,0.002132403],"genre_scores_gemma":[0.9837698,0.002518651,0.0005680959,0.0001091783,0.00002636009,0.00002179692,0.0004839684,0.00003464274,0.01246749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003770709,"threshold_uncertainty_score":0.009519637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008702773419632671,"score_gpt":0.291885679541237,"score_spread":0.2831829061216043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}