{"id":"W2072325585","doi":"10.3389/fchem.2014.00115","title":"Total synthesis of natural products using hypervalent iodine reagents","year":2015,"lang":"en","type":"review","venue":"Frontiers in Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Hypervalent molecule; Chemistry; Total synthesis; Enantioselective synthesis; Natural product; Nucleophile; Combinatorial chemistry; Organic chemistry; Phenol; Iodobenzene; Reagent; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000303818,0.0007493973,0.002872439,0.00007456138,0.00003675965,0.00003006385,0.0007838861,0.0007997598,0.0002480006],"category_scores_gemma":[0.0009146289,0.0006722976,0.0006199311,0.0004034503,0.0001990685,0.00007310501,0.0003045772,0.0008555573,0.000006220746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009207172,"about_ca_system_score_gemma":0.0004673797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000221411,"about_ca_topic_score_gemma":1.66979e-7,"domain_scores_codex":[0.9966494,0.00003553111,0.001220556,0.0009323832,0.0005906177,0.0005714478],"domain_scores_gemma":[0.9979316,0.0001159076,0.00073681,0.0009128706,0.0001256348,0.0001771535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003585441,0.0003061386,0.00007093899,0.09653178,0.0004051825,0.00005017146,0.00002239591,0.000001823043,0.02503186,2.782889e-7,0.007490809,0.8700528],"study_design_scores_gemma":[0.0003297147,0.000002837184,4.303407e-7,0.02705599,0.001081908,0.0001203641,0.00008489425,0.00008854349,0.2953115,0.00001808358,0.6748421,0.001063574],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005322219,0.989617,0.000001768351,0.000007907041,0.0004866552,0.0001587254,0.0002778434,0.00004971466,0.004078175],"genre_scores_gemma":[0.001144331,0.9918284,0.00329258,0.000002515198,0.000812714,0.00007704009,0.0002396518,0.0001427483,0.002459971],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8689892,"threshold_uncertainty_score":0.9995728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04498853017745731,"score_gpt":0.290197646176856,"score_spread":0.2452091159993987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}