{"id":"W2072338182","doi":"10.1038/sj.npp.1300502","title":"Decreased Amphetamine-Induced Locomotion and Improved Latent Inhibition in Mice Mutant for the M5 Muscarinic Receptor Gene Found in the Human 15q Schizophrenia Region","year":2004,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Nucleus accumbens; Amphetamine; Dopamine; Striatum; Dopamine receptor D2; Dopamine receptor D1; Dopamine receptor; Muscarinic acetylcholine receptor M1; Ventral tegmental area; Endocrinology; Internal medicine; Dopamine receptor D3; Biology; Muscarinic acetylcholine receptor; Receptor; Neuroscience; Medicine; Dopaminergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003986337,0.0001981064,0.0001643235,0.00007982698,0.0001617595,0.00003451922,0.0001675986,0.0001711322,0.0000116625],"category_scores_gemma":[0.00004394013,0.000143293,0.00007477989,0.0001861022,0.00006278425,0.000009125445,0.00004767232,0.0002307419,0.000001919456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000355248,"about_ca_system_score_gemma":0.00004856221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009465748,"about_ca_topic_score_gemma":0.0001871374,"domain_scores_codex":[0.9985771,0.0002294489,0.0003356794,0.0004712821,0.00008591942,0.0003005235],"domain_scores_gemma":[0.9994832,0.00005915973,0.000134534,0.0002092389,0.00006088313,0.00005293553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005623029,0.0001502764,0.0000531039,0.000014001,0.00001701196,0.0000129797,0.0001139831,0.0001956965,0.9969422,0.00009855528,0.00004913207,0.001790768],"study_design_scores_gemma":[0.01386276,0.001510126,0.01011909,0.00003271671,0.00006708191,0.0001469121,0.0001265207,0.0006371071,0.9713715,0.0007839023,0.001008102,0.0003341969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956524,0.0002408404,0.001421756,0.0009650239,0.0005406815,0.00115045,0.000004981379,0.00001081785,0.00001306448],"genre_scores_gemma":[0.9975392,0.000275289,0.0002197463,0.001270026,0.0003322795,0.0002645419,0.00005497796,0.00003011196,0.00001388687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0255707,"threshold_uncertainty_score":0.584332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173122047487711,"score_gpt":0.2840789729223993,"score_spread":0.2623477524475222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}