{"id":"W2072338182","doi":"10.1038/sj.npp.1300502","title":"Decreased Amphetamine-Induced Locomotion and Improved Latent Inhibition in Mice Mutant for the M5 Muscarinic Receptor Gene Found in the Human 15q Schizophrenia Region","year":2004,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Nucleus accumbens; Amphetamine; Dopamine; Striatum; Dopamine receptor D2; Dopamine receptor D1; Dopamine receptor; Muscarinic acetylcholine receptor M1; Ventral tegmental area; Endocrinology; Internal medicine; Dopamine receptor D3; Biology; Muscarinic acetylcholine receptor; Receptor; Neuroscience; Medicine; Dopaminergic","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483489,0.001020277,0.0003652787,0.0009766737,0.0002127005,0.0003621655,0.0004301362,0.0007827836,0.002946779],"category_scores_gemma":[0.0001586861,0.0003184829,0.0003388804,0.0002406087,0.0006311411,0.0002151315,0.0003346316,0.001096088,0.0004876063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004811509,"about_ca_system_score_gemma":0.0004077344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002541209,"about_ca_topic_score_gemma":0.004756705,"domain_scores_codex":[0.9997726,0.00003872391,0.00002764935,0.0000523167,0.00005395693,0.00005471789],"domain_scores_gemma":[0.9997445,0.00001630706,0.0001088415,0.00002001713,0.00001366451,0.00009671859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002944751,0.00006144642,0.0002733859,0.00001594636,0.00001448822,0.00007347885,0.000024176,0.00004947011,0.9981838,0.0001293271,0.00004591879,0.0008339894],"study_design_scores_gemma":[0.0003666345,0.001528208,0.03265334,0.00004743263,0.0001804642,0.001598641,0.0001411273,0.002397917,0.957267,0.000356648,0.003416275,0.00004631928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970731,0.0003241731,0.0009920965,0.0001248866,0.0000269507,0.00001371386,0.0007234874,0.0001748639,0.0005466907],"genre_scores_gemma":[0.9908477,0.0004299889,0.002186225,0.0001029496,0.000008632485,0.00006740954,0.0008828389,0.0001182126,0.005356098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002946779,"threshold_uncertainty_score":0.009857893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173122047487711,"score_gpt":0.2840789729223993,"score_spread":0.2623477524475222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}