{"id":"W2072370732","doi":"10.1371/journal.pone.0024937","title":"Notch3 Is Dispensable for Thymocyte β-Selection and Notch1-Induced T Cell Leukemogenesis","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Vanderbilt-Ingram Cancer Center; Hospital for Sick Children; Vanderbilt University","keywords":"Thymocyte; T cell; Biology; Ligand (biochemistry); Progenitor cell; Cell biology; CD8; Double negative; Lymphopoiesis; Negative selection; Receptor; Stem cell; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007787396,0.0001047593,0.0001081358,0.00002545029,0.0001019214,0.000006989369,0.00005778391,0.000156546,0.00004071353],"category_scores_gemma":[0.0000131504,0.000102863,0.00003400133,0.00004297387,0.00002328683,0.00000461994,0.00003955498,0.00002938982,0.00001631073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001133497,"about_ca_system_score_gemma":0.00003187564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001549175,"about_ca_topic_score_gemma":0.00003678218,"domain_scores_codex":[0.9993818,0.00001667638,0.0001141387,0.0002709668,0.00005287537,0.0001635806],"domain_scores_gemma":[0.9997292,0.000005839594,0.00004808935,0.0001119405,0.0000585038,0.00004646049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001645591,0.0001945055,0.009599128,0.00003415738,0.00008859646,1.393153e-7,0.00007597618,1.834905e-7,0.9883152,0.00001319059,0.0001734626,0.001340854],"study_design_scores_gemma":[0.0004309567,0.0003068527,0.01450443,0.00000838401,0.00005265479,0.000001879005,0.00001656222,0.00007180491,0.9838177,0.0001117462,0.0005313159,0.0001457438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980168,0.0001969944,0.0003482102,0.00005226778,0.00003594479,0.0002547397,0.00001081912,0.00001214522,0.001072075],"genre_scores_gemma":[0.9907477,0.0001378236,0.006526376,0.0002112584,0.00008749178,0.00004882327,0.00008607496,0.00001483587,0.002139627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007269114,"threshold_uncertainty_score":0.4194632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05572683473850786,"score_gpt":0.2143901927163282,"score_spread":0.1586633579778204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}