{"id":"W2072375322","doi":"10.1074/jbc.m110.165134","title":"B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+ Exchanger","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Tufts University School of Medicine; Fondation pour la Recherche Médicale; University of Alberta; Heart and Stroke Foundation of Canada","keywords":"Kinase; Intracellular pH; MAPK/ERK pathway; Intracellular; Protein kinase A; Cytosol; Molecular biology; Chemistry; Cell growth; HEK 293 cells; Phosphorylation; Biology; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002857941,0.00009972876,0.0001516175,0.000004894752,0.00006380938,0.000008820786,0.0002429262,0.0001546121,0.0001140061],"category_scores_gemma":[0.0001099857,0.00003889106,0.0001052559,0.00004335373,0.0001580161,0.000003339929,0.00009024837,0.0001605433,1.693662e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006585071,"about_ca_system_score_gemma":0.00002812322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003119841,"about_ca_topic_score_gemma":4.851365e-7,"domain_scores_codex":[0.999442,0.00003233078,0.0001973022,0.00009875582,0.0001045072,0.0001251272],"domain_scores_gemma":[0.9993712,0.0000270848,0.0003327023,0.0001227131,0.0001037465,0.00004253204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001172689,0.00003606785,0.008883193,0.000009173349,0.00007118787,0.000001003949,0.00007450792,6.64054e-7,0.990224,0.000008869812,0.00007959532,0.0004944572],"study_design_scores_gemma":[0.0002192543,0.0002653224,0.007369835,0.00002647851,0.00001898579,0.00006913026,0.0003192404,0.000001574137,0.9907053,0.000220362,0.0007184782,0.00006601628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982779,0.0008187863,0.00008036577,0.0001002141,0.00004090874,0.00003999975,0.000004108283,0.000001494357,0.0006362007],"genre_scores_gemma":[0.9990835,0.0002595653,0.0002890272,0.00009211391,0.0001376322,0.000001709295,0.000001426065,0.000005563608,0.0001294908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513358,"threshold_uncertainty_score":0.1585931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424978022931444,"score_gpt":0.216372127398287,"score_spread":0.1921223471689726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}