{"id":"W2072382359","doi":"10.1016/j.ijcard.2007.04.078","title":"Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: Results of the BREATHE-5 open-label extension study","year":2007,"lang":"en","type":"article","venue":"International Journal of Cardiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":243,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Eli Lilly and Company","keywords":"Bosentan; Medicine; Eisenmenger syndrome; Endothelin receptor antagonist; Placebo; Internal medicine; Cardiology; Pulmonary hypertension; Endothelin receptor; Anesthesia; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00133111,0.000132175,0.0004835402,0.000289148,0.0000399332,0.00001385306,0.0004084163,0.00008281324,0.00001849307],"category_scores_gemma":[0.000241478,0.00007682631,0.0001555686,0.0001434565,0.0001383981,0.0001386825,0.000162771,0.0003566037,0.000003706444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175386,"about_ca_system_score_gemma":0.0001600732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005648928,"about_ca_topic_score_gemma":0.00001640036,"domain_scores_codex":[0.997923,0.0002102809,0.000684001,0.0001983317,0.0007812573,0.0002030887],"domain_scores_gemma":[0.9982647,0.0002471773,0.0003343634,0.0002502754,0.0007922352,0.0001112143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02581089,0.004345589,0.8300486,0.000006555747,0.002684484,0.02041293,0.0002753577,0.00003273807,0.09866305,0.00003703529,0.001340704,0.01634207],"study_design_scores_gemma":[0.01571769,0.00201261,0.9679999,0.00007563468,0.00004358677,0.01190662,0.0002661169,0.00001041456,0.001391169,0.000167711,0.0003498068,0.00005878671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963664,0.0003660352,0.00004058476,0.0009766759,0.0009941906,0.0004399525,0.00002290747,0.000003130004,0.0007900735],"genre_scores_gemma":[0.9990024,0.0001761242,0.0001008591,0.0002256752,0.0002333171,0.000004502753,0.000008387877,0.00001082842,0.0002379249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1379513,"threshold_uncertainty_score":0.3132886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1096489168437592,"score_gpt":0.3665925341233887,"score_spread":0.2569436172796295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}