{"id":"W2072401586","doi":"10.1016/j.febslet.2011.10.018","title":"The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response","year":2011,"lang":"en","type":"article","venue":"FEBS Letters","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Acetylation; Histone H3; Methyltransferase; Provirus; Chemistry; Histone; Histone deacetylase inhibitor; Histone deacetylase; Chromatin remodeling; Molecular biology; Cancer research; Cell biology; Biology; Biochemistry; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006258353,0.0001552644,0.0001880139,0.0001214333,0.000221359,0.00001040237,0.0001648476,0.00009611872,0.000163436],"category_scores_gemma":[0.0001480243,0.00009685876,0.0000749606,0.000171834,0.0003467254,0.00007659721,0.00002972739,0.000316267,0.0003863882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006905572,"about_ca_system_score_gemma":0.0001043102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005935935,"about_ca_topic_score_gemma":0.00007977544,"domain_scores_codex":[0.9983789,0.0007094534,0.00023763,0.0002615179,0.00005328913,0.0003591767],"domain_scores_gemma":[0.9993159,0.0001758734,0.00007106004,0.0003397706,0.00006742612,0.00003000326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003251149,0.0001384288,0.006371135,0.00001278788,0.0001621499,0.00001676382,0.004740168,8.221583e-7,0.9790255,0.000008480267,0.005118119,0.001154466],"study_design_scores_gemma":[0.001216295,0.000338564,0.01519283,0.00002945121,0.00003780883,0.00001967674,0.0007905007,2.619896e-7,0.9743468,0.000005361472,0.007918128,0.0001043432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964431,0.0005322468,0.0001456465,0.001907807,0.0003026261,0.0004436656,0.00008433657,0.00004590328,0.00009470377],"genre_scores_gemma":[0.9983214,0.00003818146,0.0001322432,0.0001590056,0.00002597359,0.00007783194,0.0000764928,0.00001712685,0.001151764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008821693,"threshold_uncertainty_score":0.4966367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449548368314252,"score_gpt":0.2438514423885361,"score_spread":0.2193559587053936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}