{"id":"W2072471482","doi":"10.1016/j.bpj.2008.12.2349","title":"On the Role of Helix-Disrupting Amino Acid Residues in Supporting the Activity of Helical Antimicrobial Peptides Isolated from Australian Tree Frogs","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Antimicrobial peptides; Peptide; Amino acid; Amphiphile; Chemistry; Peptide sequence; Aqueous solution; Antimicrobial; Alpha helix; Solubility; Helix (gastropod); Stereochemistry; Frog Skin; Monomer; Protein folding; Proline; Crystallography; Circular dichroism; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001967981,0.0001617914,0.0001959637,0.0001489925,0.0001896597,0.0002630474,0.0001829488,0.000229725,0.001043268],"category_scores_gemma":[0.0002720055,0.00008569424,0.0001812284,0.0001047457,0.000301139,0.0001854223,0.0001142852,0.0003365981,0.0002952869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009604589,"about_ca_system_score_gemma":0.0001608719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502739,"about_ca_topic_score_gemma":0.0003313487,"domain_scores_codex":[0.9999441,0.00001632396,0.000005529389,0.000008373504,0.00001050557,0.00001529288],"domain_scores_gemma":[0.9997594,0.00007815802,0.00004702129,0.00001825283,0.00002706979,0.00007010557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003885834,0.00001662641,0.001296433,0.0000438496,0.000007740217,0.000164993,0.00004346548,0.0001608492,0.9961531,0.0001257573,0.00001067833,0.001588027],"study_design_scores_gemma":[0.00004394159,0.001461389,0.05314555,0.00002967812,0.00008275232,0.001298935,0.0002109691,0.001436168,0.9395921,0.0002272262,0.002455885,0.00001534295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988494,0.0002905192,0.0003551214,0.0000206668,0.000003150898,0.000004725062,0.00002649192,0.000003124893,0.0004469331],"genre_scores_gemma":[0.9988202,0.0001688426,0.0006555846,0.00002538701,0.000004216566,0.000002359102,0.00007172987,0.000002817746,0.0002488664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043268,"threshold_uncertainty_score":0.003490031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128450771525495,"score_gpt":0.2505308709272268,"score_spread":0.2376857937746773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}