{"id":"W2072504660","doi":"10.1074/jbc.m807530200","title":"MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":302,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research; Alzheimer Society; National Alliance for Research on Schizophrenia and Depression","keywords":"microRNA; Messenger RNA; Translation (biology); Untranslated region; Biology; Amyloid precursor protein; Gene expression; Three prime untranslated region; Regulation of gene expression; BACE1-AS; Gene; Molecular biology; Cell biology; Alzheimer's disease; Genetics; Disease; Medicine; Pathology; Transgene; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289078,0.0002313308,0.0001988941,0.0001254253,0.0001036429,0.0002506177,0.0001248195,0.0001692267,0.0005307265],"category_scores_gemma":[0.0002640625,0.0001598145,0.0001971025,0.00004836012,0.0001172845,0.0001074681,0.000109339,0.0002170534,0.0003104122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992249,"about_ca_system_score_gemma":0.00013522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003091175,"about_ca_topic_score_gemma":0.0004348218,"domain_scores_codex":[0.999896,0.00001939877,0.000008241859,0.0000250249,0.00003780373,0.00001354565],"domain_scores_gemma":[0.9999089,0.00002436024,0.00003254008,0.000005912047,0.00001341224,0.00001472733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002028779,0.00002997859,0.0009821965,0.00002711017,0.000005195036,0.0001362523,0.00002027898,0.000411217,0.995276,0.0002650927,0.00006215401,0.002581686],"study_design_scores_gemma":[0.00005871852,0.0003940737,0.01907296,0.00001360385,0.00003385047,0.000802579,0.0000665851,0.01960533,0.9556789,0.0005974707,0.003659009,0.00001697722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932481,0.0009579435,0.003944392,0.0000474732,0.00001959111,0.00001926803,0.0001715828,0.00007510767,0.001516693],"genre_scores_gemma":[0.9923644,0.0004366003,0.005803937,0.00002765002,0.000004552767,0.00002504414,0.000277103,0.0000155333,0.001045241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005307265,"threshold_uncertainty_score":0.001775444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03417214665785368,"score_gpt":0.2810200473580562,"score_spread":0.2468479007002026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}