{"id":"W2072505941","doi":"10.1016/s1359-6446(03)02704-1","title":"Decreasing smoking behaviour and risk through CYP2A6 inhibition","year":2003,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"CYP2A6; Nicotine; Nicotine dependence; Cigarette smoking; Medicine; Pharmacology; Bioinformatics; Biotechnology; Cytochrome P450; Biology; Internal medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004764695,0.0005380214,0.0013452,0.0001924781,0.0002347687,0.0002085899,0.00007090293,0.0004171409,0.0000836912],"category_scores_gemma":[0.00009796953,0.0004425742,0.000447497,0.00032954,0.0001003101,0.0005550783,0.00006350637,0.0008292,0.000007868501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235259,"about_ca_system_score_gemma":0.0002591088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003053315,"about_ca_topic_score_gemma":0.00001200159,"domain_scores_codex":[0.9975466,0.0002899253,0.0006438394,0.0006731114,0.000479954,0.0003665278],"domain_scores_gemma":[0.9986815,0.0001349724,0.0005116804,0.0004939547,0.00005463177,0.0001232739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002997482,0.0004086928,0.09881049,0.009054048,0.0003462756,0.0002394485,0.0008211687,5.678637e-7,0.000001568926,0.0007337472,0.001647612,0.8879064],"study_design_scores_gemma":[0.001602119,0.0001128554,0.01212855,0.04693771,0.01920556,0.001106979,0.000436698,0.000001009197,0.00007441155,0.000429787,0.9166708,0.001293499],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07250626,0.9237518,0.0001612401,0.00001685782,0.0006006499,0.000829663,0.0001372431,0.00009370973,0.001902572],"genre_scores_gemma":[0.008929758,0.9884399,0.0001203687,0.00007560071,0.0002617868,0.0000906257,0.000921703,0.000116004,0.001044276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9150232,"threshold_uncertainty_score":0.9998026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.038946726175641,"score_gpt":0.332399120459996,"score_spread":0.293452394284355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}