{"id":"W2072519673","doi":"10.1038/nature14096","title":"Protein quality control at the inner nuclear membrane","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; Agence Nationale de la Recherche","keywords":"Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Inner membrane; Cell biology; Integral membrane protein; Membrane protein; Nuclear lamina; Protein degradation; Nuclear membrane; Biology; Cytoplasm; Nuclear pore; Nuclear protein; Membrane contact site; Chemistry; Biochemistry; Unfolded protein response; Membrane; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786621,0.0001009907,0.00009272866,0.000006967353,0.0001099218,0.00001918043,0.0001707264,0.000507106,0.0001023561],"category_scores_gemma":[0.0002996901,0.00006141379,0.00008707995,0.00003131253,0.00007468153,0.000001414833,0.00007085637,0.0003799194,0.00003605972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006797016,"about_ca_system_score_gemma":0.00001448056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001069625,"about_ca_topic_score_gemma":0.00002639855,"domain_scores_codex":[0.9992702,0.0001198257,0.0001024518,0.000218184,0.0001371332,0.0001521832],"domain_scores_gemma":[0.9994217,0.00001728451,0.00005229971,0.0003910522,0.00004947887,0.00006814769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003177747,0.00004997968,0.001072136,0.00003480028,0.00004504831,0.000001997754,0.00001904974,0.00003326414,0.9703448,0.004293481,0.02262466,0.001163043],"study_design_scores_gemma":[0.001935524,0.0001169706,0.005988128,0.00001598884,0.00003064637,0.000007530108,0.00003253021,0.0001183899,0.2452839,0.0002293305,0.7459804,0.0002606189],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880953,0.0007628117,0.00003745773,0.002473362,0.0001090491,0.0002021143,0.00003984633,0.0000135596,0.008266458],"genre_scores_gemma":[0.9934719,0.00001496163,0.0000378786,0.003924632,0.0002452079,0.00001757507,0.00004932765,0.00001417435,0.002224296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7250608,"threshold_uncertainty_score":0.3911266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003426133634139712,"score_gpt":0.2408146675361496,"score_spread":0.2373885339020099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}