{"id":"W2072559701","doi":"10.1097/wad.0b013e318215aaf4","title":"Extended Kindred With Recessive Late-Onset Alzheimer Disease Maps to Locus 8p22-p21.2","year":2011,"lang":"en","type":"article","venue":"Alzheimer Disease & Associated Disorders","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Genetics; Biology; Locus (genetics); Genetic linkage; Population; Single-nucleotide polymorphism; Genotyping; Candidate gene; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000292725,0.001151194,0.001019885,0.0005680086,0.0005804617,0.0001267596,0.0005797587,0.0002606253,0.001834361],"category_scores_gemma":[0.00034785,0.0009603457,0.0006485226,0.001457714,0.0005115413,0.00055806,0.0002661723,0.0005843211,0.001669074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123779,"about_ca_system_score_gemma":0.00166855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006544876,"about_ca_topic_score_gemma":0.0002289727,"domain_scores_codex":[0.9930907,0.0004532965,0.0007933347,0.001720743,0.001844177,0.00209774],"domain_scores_gemma":[0.9910279,0.0001668275,0.0004053393,0.001565601,0.0006029092,0.006231451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03417841,0.01520397,0.8205156,0.00008479137,0.08421034,0.004503223,0.001060687,0.00003075349,0.000007633203,0.0001716331,0.02511785,0.01491514],"study_design_scores_gemma":[0.01286698,0.001297727,0.9495424,0.0004483281,0.02936461,0.000008157123,0.0004483896,0.00012098,0.0001842216,0.002736628,0.001353358,0.001628192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8332855,0.06357442,0.00009119242,0.009719806,0.0008586996,0.05710578,0.006408609,0.002827184,0.02612878],"genre_scores_gemma":[0.9884098,0.0002392062,0.0002401231,0.001647329,0.00009758683,0.006878485,0.001953839,0.0003058807,0.0002278207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1551242,"threshold_uncertainty_score":0.9992847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108883304269554,"score_gpt":0.2892761112146766,"score_spread":0.2581872781719811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}