{"id":"W2072584472","doi":"10.1038/ncb919","title":"Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation","year":2003,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université du Québec; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Signal transducing adaptor protein; Phosphotyrosine-binding domain; Biology; SH3 domain; HAMP domain; Immune system; Signal transduction; Receptor; Protein kinase domain; Tyrosine kinase; Binding domain; Biochemistry; Binding site; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230261,0.0002046276,0.0002793936,0.0001186834,0.0002435108,0.0003738111,0.0004136943,0.0005259038,0.001945266],"category_scores_gemma":[0.00009849655,0.0001776501,0.0002817127,0.0001377389,0.00023072,0.0004302202,0.0002391931,0.0005888234,0.0006199483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463774,"about_ca_system_score_gemma":0.0001290784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004996229,"about_ca_topic_score_gemma":0.0005569829,"domain_scores_codex":[0.9999318,0.000006645957,0.000002235582,0.00001452656,0.00001825977,0.00002649176],"domain_scores_gemma":[0.9999534,0.000008837706,0.000007604685,0.000007343757,0.000006632419,0.00001613667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002071011,0.0000125415,0.0002397908,0.00002815182,0.000005796026,0.0002253724,0.0000176477,0.0001339089,0.9960608,0.001054243,0.0001373923,0.001877306],"study_design_scores_gemma":[0.00003619361,0.0001836824,0.01624503,0.000006872634,0.00002048708,0.001835288,0.00006767243,0.006714843,0.9679487,0.001776251,0.005145915,0.00001902638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798506,0.001512659,0.01448734,0.000258773,0.00004643133,0.00001637702,0.0002152151,0.0001412138,0.003471239],"genre_scores_gemma":[0.9925599,0.0003433901,0.003377127,0.0001244444,0.00001928634,0.00001284844,0.0002662058,0.00001111881,0.003285733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945266,"threshold_uncertainty_score":0.006507516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007693149281940955,"score_gpt":0.2321420635706182,"score_spread":0.2244489142886772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}