{"id":"W2072586810","doi":"10.1016/s0960-894x(02)00439-0","title":"Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and d-2′-deoxyribonucleosides (2′F-ANA/DNA ‘Altimers’) induce efficient RNA cleavage mediated by RNase H","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"RNase H; Oligonucleotide; RNase P; Chemistry; RNA; DNA; Molecular biology; Ribonuclease; Ribonuclease III; Nucleotide; RNase MRP; Nucleic acid; Biochemistry; Biology; Gene; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005903252,0.0008578259,0.0004307371,0.0002798329,0.0002191938,0.0003508678,0.0002138494,0.0006539738,0.001640256],"category_scores_gemma":[0.0004298911,0.0004824591,0.0003532166,0.0001499768,0.0002962764,0.0002839419,0.0002380732,0.0005361415,0.0009921158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002346418,"about_ca_system_score_gemma":0.0001992061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001575466,"about_ca_topic_score_gemma":0.000374274,"domain_scores_codex":[0.9996025,0.00009778275,0.00002935716,0.0001200292,0.00006888174,0.00008150443],"domain_scores_gemma":[0.9995754,0.0001560127,0.0001114459,0.00004140109,0.00003655497,0.00007913024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005722128,0.00000802935,0.00002117436,0.00001627306,0.000002994586,0.00001845301,0.000008942783,0.00003251295,0.9992962,0.0000535984,0.00001146472,0.0004732496],"study_design_scores_gemma":[0.00001520492,0.0002123555,0.0002515275,0.000002465294,0.000006758982,0.00008863716,0.000004635392,0.0001650197,0.9985839,0.00002394716,0.0006423981,0.000003116251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609535,0.001264172,0.03247729,0.00008974443,0.0001569552,0.000178181,0.0002212845,0.0006204478,0.004038436],"genre_scores_gemma":[0.9704882,0.0006377536,0.0236246,0.0001423965,0.00005444027,0.000144615,0.0004304585,0.00008666408,0.004390806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640256,"threshold_uncertainty_score":0.005487204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007530681494696286,"score_gpt":0.1974949652260143,"score_spread":0.189964283731318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}