{"id":"W2072586810","doi":"10.1016/s0960-894x(02)00439-0","title":"Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and d-2′-deoxyribonucleosides (2′F-ANA/DNA ‘Altimers’) induce efficient RNA cleavage mediated by RNase H","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"RNase H; Oligonucleotide; RNase P; Chemistry; RNA; DNA; Molecular biology; Ribonuclease; Ribonuclease III; Nucleotide; RNase MRP; Nucleic acid; Biochemistry; Biology; Gene; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003457816,0.0006510553,0.0006554225,0.00006159003,0.0002089133,0.00005300582,0.0006832662,0.0003953673,0.0003601915],"category_scores_gemma":[0.0004033083,0.0006479398,0.000191368,0.0002728071,0.0007423786,0.00001717751,0.0003206797,0.0004555957,0.00002154132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008563059,"about_ca_system_score_gemma":0.00004625845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009343104,"about_ca_topic_score_gemma":0.00000203474,"domain_scores_codex":[0.9966004,0.00007256756,0.0008878595,0.001011372,0.0006518622,0.000775864],"domain_scores_gemma":[0.9979534,0.0001032233,0.0005439554,0.0007717436,0.0001152774,0.0005124576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008336407,0.0001935958,0.001028107,0.00024526,0.000200252,0.00004404102,0.0002093293,0.000006684951,0.9737837,0.000001101993,0.02306321,0.001141355],"study_design_scores_gemma":[0.001820917,0.0001013781,0.0005473432,0.0001652964,0.0001351193,0.0001288726,0.000420434,0.0004646216,0.9930083,0.000002556726,0.002566251,0.0006389321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931872,0.003134175,0.0000896163,0.001857351,0.0001449812,0.0002304556,0.0001159039,0.00008491369,0.001155377],"genre_scores_gemma":[0.9968312,0.0005676802,0.0003412903,0.001310499,0.0004344792,0.00001382915,0.0002001103,0.0001140024,0.0001868715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02049696,"threshold_uncertainty_score":0.9995972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007530681494696286,"score_gpt":0.1974949652260143,"score_spread":0.189964283731318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}