{"id":"W2072590237","doi":"10.1172/jci17220","title":"The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Furin; Proprotein Convertases; Angiogenesis; Proprotein convertase; Cell biology; Molecular biology; Chemistry; Cleavage (geology); Carcinogenesis; Biology; Cancer research; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009485436,0.0003341053,0.0001379416,0.0002580569,0.000123959,0.0002444329,0.00009183805,0.0001784485,0.001090027],"category_scores_gemma":[0.00009120514,0.00008435291,0.0002283351,0.0001394767,0.000122919,0.0001284278,0.0001480561,0.0004554318,0.0003723408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377829,"about_ca_system_score_gemma":0.0002697545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008906162,"about_ca_topic_score_gemma":0.0008862051,"domain_scores_codex":[0.9999177,0.00001017527,0.000004798789,0.00001243048,0.00002617876,0.0000286526],"domain_scores_gemma":[0.9999219,0.00001321567,0.00001552892,0.000008068455,0.00001044855,0.00003078829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005687553,0.00001609359,0.0001855353,0.00001603003,0.000003267292,0.00004253907,0.00000732505,0.00004926348,0.9977088,0.000148657,0.00004156213,0.001724174],"study_design_scores_gemma":[0.000008211585,0.0001124589,0.002558624,0.00000293333,0.00000652508,0.0001667275,0.000009724631,0.0006997549,0.9942281,0.00005232337,0.002152717,0.000001899475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867663,0.001719897,0.007442864,0.00007803543,0.00003004442,0.00006659343,0.0004337496,0.000141315,0.003321212],"genre_scores_gemma":[0.9877146,0.0008848012,0.006461166,0.00004248715,0.000009286504,0.00003281443,0.0008451476,0.00001830479,0.003991321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090027,"threshold_uncertainty_score":0.003646493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08073920457234184,"score_gpt":0.3712970140702853,"score_spread":0.2905578094979435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}