{"id":"W2072599612","doi":"10.1097/01.tp.0000072373.77323.d4","title":"Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells","year":2003,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"U.S. Public Health Service","keywords":"Monoclonal antibody; Cytotoxic T cell; Apoptosis; Cell biology; Biology; T cell; Cell; Molecular biology; CD8; Effector; Population; Antibody; In vitro; Immunology; Immune system; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000505438,0.000377511,0.0005314694,0.0002911287,0.0001835535,0.00002241319,0.0001870181,0.0004594469,0.000183317],"category_scores_gemma":[0.00001788912,0.0003691166,0.0002044854,0.0004002824,0.0001147123,0.0003052495,0.000006371723,0.0004105826,0.0001945259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008407824,"about_ca_system_score_gemma":0.0001066409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317948,"about_ca_topic_score_gemma":0.00006943318,"domain_scores_codex":[0.9972252,0.0009147496,0.0007184097,0.0005342309,0.0001019391,0.000505472],"domain_scores_gemma":[0.999007,0.0003411343,0.0002864656,0.0002437099,0.0000926241,0.00002906432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007446381,0.0005138654,0.004700862,0.00007607329,0.0001444686,0.00001099409,0.00178222,0.0001691281,0.9906572,0.0002107036,0.0004180603,0.0005717482],"study_design_scores_gemma":[0.007160475,0.0005641963,0.001891136,0.00006172168,0.0001006676,0.00002742259,0.0001505237,0.00004279947,0.9883105,0.00009342784,0.001233549,0.0003636057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857401,0.003135403,0.008266945,0.00003977375,0.0009210415,0.0008768809,0.00009599391,0.00007643815,0.0008474364],"genre_scores_gemma":[0.9958093,0.001607736,0.0002073712,0.00009429167,0.00001678483,0.00008059991,0.001627402,0.00003867105,0.0005178808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01006918,"threshold_uncertainty_score":0.9998761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007199934046884952,"score_gpt":0.2362706673912537,"score_spread":0.2290707333443688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}