{"id":"W2072620819","doi":"10.1128/jvi.01076-12","title":"Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Trimer; Gp41; Glycoprotein; Biology; Simian immunodeficiency virus; Plasma protein binding; Viral envelope; Binding site; Binding domain; Cell biology; Viral entry; Biophysics; Virology; Virus; Biochemistry; Viral replication; Chemistry; Genetics; Antibody; Dimer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217623,0.00007478494,0.00008583294,0.0001538781,0.0001092052,0.0003230208,0.0001187883,0.0001257786,0.001462097],"category_scores_gemma":[0.0001623982,0.00009182413,0.00009627963,0.00007582353,0.0001091504,0.0001505377,0.0001998059,0.0001843298,0.0002192252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153728,"about_ca_system_score_gemma":0.0001180731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008699119,"about_ca_topic_score_gemma":0.001447025,"domain_scores_codex":[0.9999048,0.00001997007,0.000005661123,0.00001863245,0.00001954956,0.0000314594],"domain_scores_gemma":[0.9999335,0.00001738331,0.00001569222,0.000008073535,0.000009868931,0.00001541766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001832481,0.00001620573,0.004951566,0.0000248525,0.000006114389,0.00005742494,0.000102878,0.00006742917,0.9887061,0.000666543,0.00007973128,0.005137718],"study_design_scores_gemma":[0.00003682292,0.0004524144,0.2976091,0.00004144323,0.00003697328,0.001177407,0.0005734119,0.002536894,0.6753668,0.0006457951,0.02150721,0.00001570251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952399,0.002117777,0.0005134615,0.00002772651,0.000005016743,0.000008385055,0.0001319137,0.00001582946,0.001939993],"genre_scores_gemma":[0.9965616,0.0008850099,0.0005350081,0.00004154492,0.000005394192,0.0000115237,0.0002591617,0.000007246581,0.001693562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001462097,"threshold_uncertainty_score":0.004891217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03462682655046433,"score_gpt":0.2889745509572361,"score_spread":0.2543477244067718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}