{"id":"W2072626787","doi":"10.1006/bbrc.2000.3385","title":"Thiol Antioxidant, N-Acetylcysteine, Activates Extracellular Signal-Regulated Kinase Signaling Pathway in Articular Chondrocytes","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"MAPK/ERK pathway; Pyrrolidine dithiocarbamate; Kinase; Chemistry; Cell biology; Glutathione; Reactive oxygen species; Signal transduction; Protein kinase A; p38 mitogen-activated protein kinases; Acetylcysteine; Antioxidant; Chondrocyte; Phosphorylation; Biochemistry; Pharmacology; Biology; NF-κB; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304072,0.000263615,0.0003177568,0.0002239149,0.0002639203,0.0003357809,0.0001521675,0.0002925796,0.001109713],"category_scores_gemma":[0.0001457841,0.0001868305,0.0003780978,0.0001624609,0.0002956883,0.0002287129,0.0001793232,0.0005344628,0.0002667855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781037,"about_ca_system_score_gemma":0.0006156314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001765609,"about_ca_topic_score_gemma":0.003725138,"domain_scores_codex":[0.99978,0.00002714061,0.00002180892,0.000033351,0.00006107762,0.00007665548],"domain_scores_gemma":[0.9998974,0.00001020353,0.00001694963,0.00001430473,0.00002599239,0.00003523697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005776471,0.00003723276,0.0002112049,0.00004771457,0.000007709345,0.00006178358,0.00002797136,0.00001877581,0.9982542,0.00004496464,0.0000495208,0.0006611873],"study_design_scores_gemma":[0.0001028448,0.0006590499,0.01699437,0.00001286733,0.0000507306,0.0002432625,0.0002407071,0.0005725925,0.9793448,0.00008947018,0.001680333,0.000008971381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956418,0.002341573,0.0008330831,0.0001641752,0.00006779114,0.00001311379,0.0001474163,0.00003036871,0.0007606836],"genre_scores_gemma":[0.9952233,0.000838622,0.0004580339,0.00006619286,0.00001378094,0.00001980864,0.0002130262,0.000005040802,0.0031622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765609,"threshold_uncertainty_score":0.003712356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574133353701225,"score_gpt":0.3099619090715079,"score_spread":0.2742205755344957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}