{"id":"W2072627772","doi":"10.1186/1471-213x-10-50","title":"Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome","year":2010,"lang":"en","type":"article","venue":"BMC Developmental Biology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Placentation; Biology; Genomic imprinting; Genetics; Epigenetics; Gene; Phenotype; Imprinting (psychology); Gene silencing; Allele; X-inactivation; Genetic screen; Placenta; X chromosome; DNA methylation; Gene expression; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002030679,0.000770516,0.0003519513,0.0008155046,0.0002912887,0.0002676098,0.000319495,0.0005882092,0.002049282],"category_scores_gemma":[0.0001667559,0.000275839,0.0003085516,0.000207742,0.000453383,0.0001838291,0.0004972277,0.0007172569,0.0004046861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977506,"about_ca_system_score_gemma":0.000298152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004071621,"about_ca_topic_score_gemma":0.0006684701,"domain_scores_codex":[0.999816,0.00003889177,0.0000204074,0.00004244215,0.00005524931,0.00002698194],"domain_scores_gemma":[0.9998166,0.00003392781,0.00005468144,0.00002817472,0.000007406584,0.00005924722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005195902,0.0001641234,0.0006124357,0.000132991,0.00003181234,0.003069813,0.00006512918,0.0003630472,0.9908614,0.001143322,0.0002383831,0.002797968],"study_design_scores_gemma":[0.0004338015,0.003973576,0.01339789,0.0001153709,0.0002390113,0.03461076,0.0002315296,0.004685211,0.9219896,0.001276745,0.01899455,0.00005197405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888416,0.00166128,0.004767104,0.0002428013,0.00008423467,0.0001186017,0.0008687505,0.0003460422,0.003069545],"genre_scores_gemma":[0.9897733,0.001660201,0.004245055,0.0001016978,0.00001914412,0.0001160308,0.0008647313,0.0000629509,0.003156867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049282,"threshold_uncertainty_score":0.006855607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489595735384027,"score_gpt":0.2401678605054921,"score_spread":0.2252719031516519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}