{"id":"W2072657902","doi":"10.1074/jbc.m114.547778","title":"Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; March of Dimes Foundation; National Institutes of Health; Bundesministerium für Bildung und Forschung; Canadian Institutes of Health Research; American Society of Hematology","keywords":"Ferritin; Heme; Protoporphyrin; Mitochondrion; Zebrafish; Biochemistry; Mutant; Porphyria; HMOX1; Ectopic expression; Biology; In vivo; Molecular biology; Iron deficiency; Chemistry; Cell biology; Internal medicine; Endocrinology; Anemia; Gene; Medicine; Enzyme; Heme oxygenase; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204127,0.0005565828,0.0007101406,0.000344386,0.0001850265,0.0002365062,0.0003555284,0.000514616,0.001070082],"category_scores_gemma":[0.000185921,0.0001926179,0.0002402364,0.0001372753,0.0002992221,0.0001797532,0.000175201,0.0009142094,0.0002736945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112298,"about_ca_system_score_gemma":0.0002407971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005528585,"about_ca_topic_score_gemma":0.0006154167,"domain_scores_codex":[0.9998879,0.00001613509,0.00001159204,0.00002724512,0.00002115841,0.00003589007],"domain_scores_gemma":[0.9998136,0.00001784642,0.00005373986,0.00001935652,0.00001850219,0.00007697842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001254997,0.0002899201,0.0001949692,0.00009375927,0.00002213697,0.0001014639,0.00002160679,0.00009718231,0.9934852,0.00009317507,0.0002221491,0.004123563],"study_design_scores_gemma":[0.000581696,0.004440422,0.01098384,0.00003380793,0.0001054165,0.0006484853,0.00006114812,0.002094145,0.9765371,0.0001591204,0.004334894,0.00001983461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961911,0.001235952,0.00122841,0.000186791,0.00006034211,0.00003671263,0.0003037459,0.0002941873,0.0004626729],"genre_scores_gemma":[0.9939225,0.0009059588,0.001333563,0.0001247229,0.00003336985,0.00006842623,0.0007767818,0.00005034753,0.002784268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070082,"threshold_uncertainty_score":0.003579795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008637850808409219,"score_gpt":0.2166269470311308,"score_spread":0.2079890962227216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}