{"id":"W2072681889","doi":"10.1139/y09-004","title":"Role of protein kinase C β<sub>2</sub>activation in TNF-α-induced human vascular endothelial cell apoptosis","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Hong Kong; National Natural Science Foundation of China","keywords":"Rottlerin; Protein kinase C; Apoptosis; Endothelial stem cell; Tumor necrosis factor alpha; Molecular biology; Superoxide dismutase; Viability assay; Reactive oxygen species; Endothelium; Biology; Oxidative stress; Chemistry; Cell biology; Biochemistry; Endocrinology; Kinase; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204207,0.0004908197,0.0002771082,0.000271243,0.0002417407,0.0005032461,0.0001690072,0.0002234918,0.001590673],"category_scores_gemma":[0.0001904576,0.0001168066,0.000244407,0.0001997615,0.0001556751,0.0002698936,0.000168534,0.0004342466,0.0005332957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00053747,"about_ca_system_score_gemma":0.0003714507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004536276,"about_ca_topic_score_gemma":0.0003433951,"domain_scores_codex":[0.9998642,0.00003080866,0.00001482346,0.00002344441,0.00002804641,0.00003875092],"domain_scores_gemma":[0.9999101,0.00001260934,0.00003688214,0.00001064699,0.00001360617,0.00001616098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001872485,0.0001640998,0.001191551,0.0002463608,0.00003108167,0.0002899326,0.00003821087,0.0001840663,0.9845665,0.0003605704,0.0002666301,0.01078854],"study_design_scores_gemma":[0.0002285142,0.001071204,0.03109979,0.00006529838,0.00007193811,0.001678432,0.00007857798,0.002033646,0.9535217,0.0003473149,0.009790195,0.00001343096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651985,0.02677906,0.002372985,0.0003408922,0.0001657307,0.00008204761,0.00050598,0.0001063275,0.004448446],"genre_scores_gemma":[0.9876789,0.008177521,0.001500389,0.0001473342,0.00004242823,0.00007941733,0.0005882415,0.00001036611,0.001775452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590673,"threshold_uncertainty_score":0.005321324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009335743504735759,"score_gpt":0.2251604603200013,"score_spread":0.2158247168152656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}