{"id":"W2072691337","doi":"10.1172/jci34584","title":"Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":506,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Antigen; CTL*; C-type lectin; Biology; Cross-presentation; Immunology; CD8; Epitope; Priming (agriculture); Dendritic cell; T cell; Immune system; Cancer research; MHC class I","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009648129,0.0001157915,0.0003747247,0.0002429728,0.0001057346,0.00001070659,0.000120974,0.0001855362,0.0002897572],"category_scores_gemma":[0.002652735,0.00009710558,0.0001332937,0.0004263192,0.0001036397,0.0002556771,0.00001971986,0.0007708292,0.0002754754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000440976,"about_ca_system_score_gemma":0.0002488504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000951249,"about_ca_topic_score_gemma":0.000007875802,"domain_scores_codex":[0.9977735,0.0003878051,0.001438715,0.0001545002,0.00006775426,0.0001777402],"domain_scores_gemma":[0.9982249,0.0004418313,0.0007852206,0.0000897316,0.0004020543,0.00005628413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001096763,0.0002867161,0.03678284,0.00000252873,0.00006300892,0.0000140558,0.0003972583,0.00008533752,0.9197477,0.00001145149,0.04008145,0.001430864],"study_design_scores_gemma":[0.006109283,0.003282215,0.5204115,0.0001429599,0.00002122663,0.0008061621,0.0002155075,0.0001630489,0.319384,0.0001567467,0.1490137,0.000293647],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892223,0.0003547965,0.001121921,0.00120989,0.007855818,0.0001340203,2.087253e-7,0.0000171942,0.00008386271],"genre_scores_gemma":[0.9943183,0.000310024,0.001740579,0.002416789,0.000245345,0.000001692689,0.00001493763,0.00001290346,0.0009394021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6003637,"threshold_uncertainty_score":0.395985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08076732815346165,"score_gpt":0.3413902789587154,"score_spread":0.2606229508052537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}