{"id":"W2072691337","doi":"10.1172/jci34584","title":"Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":506,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Antigen; CTL*; C-type lectin; Biology; Cross-presentation; Immunology; CD8; Epitope; Priming (agriculture); Dendritic cell; T cell; Immune system; Cancer research; MHC class I","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758815,0.0006054089,0.0002836477,0.0003300312,0.0001337654,0.0002623951,0.0002705001,0.0005296374,0.001116481],"category_scores_gemma":[0.00007090531,0.0001445999,0.0001721835,0.0001462672,0.000357091,0.0002674711,0.0001672137,0.001011303,0.0003867943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302339,"about_ca_system_score_gemma":0.0003014191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693672,"about_ca_topic_score_gemma":0.0004138925,"domain_scores_codex":[0.9998695,0.00002479958,0.000008308926,0.00003431447,0.00002350567,0.00003956006],"domain_scores_gemma":[0.9999441,0.000007075893,0.00002039857,0.00000835026,0.000004199683,0.00001596261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003250767,0.0002217279,0.0001219061,0.00005489679,0.000004896785,0.00005128971,0.00001127326,0.00007895147,0.9936469,0.000407633,0.0001670394,0.0049084],"study_design_scores_gemma":[0.0002283694,0.003403915,0.001872652,0.00002078991,0.00003270426,0.0008612683,0.00001461805,0.00141905,0.9749677,0.0002420064,0.01692978,0.000007223648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677163,0.007703237,0.0157096,0.001016431,0.000195234,0.000403177,0.0007225508,0.0006556918,0.005877838],"genre_scores_gemma":[0.9737048,0.003795743,0.01216917,0.0003090375,0.00005149593,0.0003275549,0.0008883866,0.00004113091,0.008712514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116481,"threshold_uncertainty_score":0.003735006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08076732815346165,"score_gpt":0.3413902789587154,"score_spread":0.2606229508052537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}