{"id":"W2072697462","doi":"10.1007/s004390051005","title":"Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes","year":2000,"lang":"en","type":"article","venue":"Human Genetics","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Nondisjunction; Biology; Aneuploidy; Trisomy; Fluorescence in situ hybridization; Molecular biology; Binucleated cells; Chromosome 21; In vivo; Chromosome; Cytogenetics; Mitosis; Genetics; Micronucleus test; Micronucleus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156068,0.0001360891,0.0002219353,0.0002057663,0.00001776096,0.000006756296,0.000106699,0.0001280987,0.00001687616],"category_scores_gemma":[0.00002768086,0.0001526352,0.0000255687,0.0002758912,0.00007645447,0.0000123874,0.00003598787,0.00004529942,4.087355e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008587454,"about_ca_system_score_gemma":0.00005478195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005770135,"about_ca_topic_score_gemma":0.0008179849,"domain_scores_codex":[0.9988139,0.00008901753,0.000592116,0.0002395911,0.0001174027,0.0001479411],"domain_scores_gemma":[0.9995182,0.00001739848,0.0002003311,0.0001668456,0.00007538794,0.00002179376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589482,0.0002480003,0.08888345,0.00007644057,0.000003393462,5.675201e-7,0.0003380225,0.002717467,0.9052791,0.000002339625,0.000003143495,0.002289133],"study_design_scores_gemma":[0.001810927,0.0003380047,0.09552996,0.0000727275,0.000005089517,8.665166e-7,0.0001076315,0.001029384,0.9009379,0.00003091708,0.00001937833,0.0001172428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990104,0.0006128996,0.000009348864,0.00000302713,0.00001643568,0.0002304791,0.00006383222,0.000002263898,0.00005134634],"genre_scores_gemma":[0.9986734,0.0009020767,0.000197579,0.000008480624,0.00001194847,0.00001468161,0.0001469202,0.00001357756,0.00003130486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006646502,"threshold_uncertainty_score":0.6224281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004382400893814021,"score_gpt":0.1966460409236936,"score_spread":0.1922636400298796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}