{"id":"W2072714001","doi":"10.1038/sj.cdd.4401602","title":"IRES in distress: translational regulation of the inhibitor of apoptosis proteins XIAP and HIAP2 during cell stress","year":2005,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"XIAP; Inhibitor of apoptosis; Apoptosis; Cell biology; Internal ribosome entry site; Chemistry; Cancer research; Programmed cell death; Biology; Translation (biology); Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000438567,0.00008812008,0.00009375594,0.0000432048,0.00004985586,0.000009292568,0.00003944481,0.00009658207,0.000007620594],"category_scores_gemma":[0.000005298335,0.00006891091,0.00003851261,0.00004714302,0.00003095617,0.00001034835,0.00003026437,0.00003487545,8.318187e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005954199,"about_ca_system_score_gemma":0.00001162064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001861804,"about_ca_topic_score_gemma":0.00004468311,"domain_scores_codex":[0.9994006,0.00003325019,0.0002131193,0.0001629238,0.0001075277,0.00008263376],"domain_scores_gemma":[0.9996921,0.000006417753,0.0001317593,0.0001101086,0.00003414542,0.00002549079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004758662,0.00008848754,0.02742097,0.000156683,0.000004251539,1.009571e-8,0.0001321919,0.0003682081,0.9697724,0.0001421863,0.000002057798,0.001864991],"study_design_scores_gemma":[0.0005169271,0.00002566216,0.3388483,0.00002784655,0.00001228196,2.459978e-7,0.00001975447,0.001046352,0.659328,0.0001091876,0.00001572573,0.00004977878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981121,0.0005675971,0.000864298,0.00004535083,0.00003635757,0.0002394618,0.00002736394,0.000002502684,0.0001049986],"genre_scores_gemma":[0.999129,0.0001861382,0.0002933471,0.00000314638,0.00006331736,0.000009481012,0.0001296441,0.000007276533,0.0001786534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3114273,"threshold_uncertainty_score":0.2810105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004292670704490353,"score_gpt":0.1853840123108226,"score_spread":0.1810913416063322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}