{"id":"W2072720662","doi":"10.1371/journal.pone.0096891","title":"Stimulus-Selective Regulation of Human Mast Cell Gene Expression, Degranulation and Leukotriene Production by Fluticasone and Salmeterol","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Institute for Nanotechnology","funders":"National Heart, Lung, and Blood Institute; National Research Council Canada; National Institutes of Health; GlaxoSmithKline; American Academy of Allergy Asthma and Immunology","keywords":"Degranulation; Salmeterol; Immunoglobulin E; Chemistry; Cytokine; Fluticasone propionate; Chemokine; Prostaglandin D2; Pharmacology; Tumor necrosis factor alpha; Mast cell; Fluticasone; Internal medicine; Endocrinology; Immunology; Inflammation; Biology; Medicine; Receptor; Asthma; Biochemistry; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600472,0.0002260424,0.0002061072,0.0001508666,0.00009200898,0.0002412544,0.0001090375,0.000183242,0.001453693],"category_scores_gemma":[0.0001444659,0.0001092674,0.000326978,0.000158051,0.0001334514,0.0001187352,0.000144089,0.0003102506,0.0003054074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645444,"about_ca_system_score_gemma":0.0001721006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236517,"about_ca_topic_score_gemma":0.0007332234,"domain_scores_codex":[0.9998025,0.00003820924,0.00001916266,0.00002794089,0.00003807894,0.00007413663],"domain_scores_gemma":[0.999943,0.00001653321,0.00001233472,0.000008026735,0.000007391051,0.00001277052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003586455,0.0000291518,0.0001768403,0.00002868633,0.000002411075,0.0000537941,0.00001588991,0.00001926574,0.9982481,0.00001738787,0.00003954174,0.001010326],"study_design_scores_gemma":[0.00008549086,0.001227022,0.02188316,0.000009632069,0.00002104606,0.0003629443,0.00006839099,0.0006031125,0.9728056,0.00004171108,0.002884031,0.000007951896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939656,0.003134302,0.001050937,0.0001277811,0.00004554639,0.00005042968,0.0006714044,0.00003438874,0.0009197658],"genre_scores_gemma":[0.9939433,0.001508847,0.001893831,0.0001440502,0.00003320946,0.0001095526,0.001030064,0.000006988299,0.00133017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453693,"threshold_uncertainty_score":0.004863083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003782785221666,"score_gpt":0.2304298639322103,"score_spread":0.2103920360799936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}