{"id":"W2072728217","doi":"10.1182/blood.v98.4.1078","title":"Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ontario HIV Treatment Network","keywords":"Nelfinavir; Apoptosis; Caspase; Saquinavir; Protease; Ritonavir; Cell biology; Caspase-9; Mitochondrion; Biology; Caspase 3; Chemistry; Pharmacology; Biochemistry; Programmed cell death; Enzyme; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571587,0.0003548888,0.0003254349,0.0003466073,0.0002167616,0.0006531295,0.0003741113,0.0004551185,0.0018974],"category_scores_gemma":[0.0002052745,0.0001214178,0.0001893323,0.0001655266,0.0002063933,0.0004836247,0.0001753113,0.0005112694,0.000483672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966775,"about_ca_system_score_gemma":0.0001377882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104093,"about_ca_topic_score_gemma":0.0001830799,"domain_scores_codex":[0.9998685,0.0000374862,0.000007544908,0.0000129451,0.00003278253,0.00004079914],"domain_scores_gemma":[0.999929,0.00001760427,0.00002057441,0.000007430736,0.00001306889,0.00001232081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001795752,0.000442858,0.001014717,0.0007250395,0.00008145824,0.0007150273,0.00007220434,0.0003767128,0.8660896,0.005630482,0.001954017,0.1211021],"study_design_scores_gemma":[0.0004571901,0.003200086,0.006791307,0.00006652407,0.00009101264,0.005051674,0.00004851971,0.001454116,0.955835,0.0009752825,0.02601435,0.00001492045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8444353,0.1310419,0.007408726,0.001569315,0.0003010977,0.000140509,0.0004102084,0.0002606474,0.01443224],"genre_scores_gemma":[0.9739521,0.02128026,0.001730919,0.0002931126,0.0001278301,0.00004535824,0.0002293328,0.00000829358,0.002332712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018974,"threshold_uncertainty_score":0.006347418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867603037829704,"score_gpt":0.2255433754639587,"score_spread":0.217675772426129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}