{"id":"W2072728217","doi":"10.1182/blood.v98.4.1078","title":"Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss","year":2001,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ontario HIV Treatment Network","keywords":"Nelfinavir; Apoptosis; Caspase; Saquinavir; Protease; Ritonavir; Cell biology; Caspase-9; Mitochondrion; Biology; Caspase 3; Chemistry; Pharmacology; Biochemistry; Programmed cell death; Enzyme; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149941,0.0002218244,0.0003968203,0.0001479364,0.00007511313,0.00001436374,0.00008543338,0.0001123626,0.0002776297],"category_scores_gemma":[0.00003432217,0.0001895284,0.0002115554,0.0002283471,0.00004635818,0.00009074374,0.00002836134,0.0001378001,0.00006721064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001995625,"about_ca_system_score_gemma":0.0001360042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000095861,"about_ca_topic_score_gemma":0.000002233909,"domain_scores_codex":[0.9984244,0.00004652742,0.0004552246,0.0003215417,0.0004141847,0.0003381361],"domain_scores_gemma":[0.9993689,0.00001756323,0.0001257191,0.0002475303,0.00007851998,0.0001617332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001836174,0.01746466,0.03956673,0.001538423,0.002662466,0.005499184,0.003152738,0.00001644074,0.920934,0.001180384,0.00108849,0.005060296],"study_design_scores_gemma":[0.02554646,0.0004039537,0.001486393,0.0008148974,0.001906784,0.0008337861,0.0001596736,0.0001280023,0.9666612,0.0004536847,0.00120472,0.0004004861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950281,0.0001475002,0.001218988,0.001023785,0.0002341063,0.00117798,0.00001094634,0.00008886951,0.001069691],"genre_scores_gemma":[0.986358,0.00005028012,0.006295644,0.00002336305,0.0004918867,0.00005424181,0.00006526797,0.0000353889,0.006625872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04572713,"threshold_uncertainty_score":0.7728745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867603037829704,"score_gpt":0.2255433754639587,"score_spread":0.217675772426129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}