{"id":"W2072748745","doi":"10.1074/jbc.m002092200","title":"The Forgotten Serine","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Mental Health","keywords":"Chemistry; Stereochemistry; Partial agonist; Agonist; Adenylyl cyclase; Alprenolol; Serine; Cysteine; Affinities; Pindolol; SCH-23390; Receptor; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293546,0.0006552047,0.0005642067,0.0003321087,0.001109403,0.001934443,0.0006713645,0.001002809,0.08121338],"category_scores_gemma":[0.001194136,0.0001777085,0.0004890523,0.0006212246,0.000802968,0.001885254,0.001375811,0.001409051,0.046016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000557963,"about_ca_system_score_gemma":0.0007321767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634699,"about_ca_topic_score_gemma":0.0006284769,"domain_scores_codex":[0.9997157,0.0000370887,0.00001937542,0.00008991903,0.0000756489,0.0000620853],"domain_scores_gemma":[0.9996794,0.00004679963,0.00005121043,0.00007766525,0.00005658598,0.00008831423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001875366,0.0001144715,0.002785903,0.001969851,0.0002090527,0.006320648,0.001814081,0.0004292951,0.1590634,0.1866891,0.2046506,0.4340781],"study_design_scores_gemma":[0.00004989723,0.0001216461,0.001137446,0.0002063401,0.00003652165,0.003210249,0.0003842621,0.0001797694,0.01473939,0.01559924,0.9642954,0.00003977521],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1507274,0.06800331,0.03463388,0.02782799,0.02717753,0.0002200768,0.01031521,0.003609171,0.6774855],"genre_scores_gemma":[0.4576452,0.02543216,0.01743718,0.01327277,0.001946228,0.000120288,0.01201662,0.0008416817,0.4712878],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.08121338,"threshold_uncertainty_score":0.2716858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087019183030389,"score_gpt":0.2323643742059643,"score_spread":0.2214941823756604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}