{"id":"W2072748745","doi":"10.1074/jbc.m002092200","title":"The Forgotten Serine","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Mental Health","keywords":"Chemistry; Stereochemistry; Partial agonist; Agonist; Adenylyl cyclase; Alprenolol; Serine; Cysteine; Affinities; Pindolol; SCH-23390; Receptor; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002965978,0.00008985509,0.0001151761,0.00000331461,0.00009299395,0.00002393434,0.0002712526,0.0001366991,0.0008671578],"category_scores_gemma":[0.00008156583,0.00004672123,0.00015202,0.00003443585,0.0000632569,0.000001919186,0.00003151052,0.0001368224,0.000006126797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007087373,"about_ca_system_score_gemma":0.00002670707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.307466e-7,"about_ca_topic_score_gemma":1.255291e-7,"domain_scores_codex":[0.9993544,0.00002393676,0.0002620794,0.0001019275,0.00009616099,0.0001614878],"domain_scores_gemma":[0.9995835,0.00002023851,0.0001164207,0.0001305305,0.00007056502,0.00007871665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001404834,0.00002063338,0.0002233624,0.000002520862,0.00002876856,0.000006130998,0.000002832429,0.00002221211,0.9839726,0.000006847354,0.001265788,0.0143078],"study_design_scores_gemma":[0.0002086653,0.0001969229,0.000204423,0.000005924089,0.000004752052,0.0001614427,0.00003277152,0.00000651652,0.7690844,0.0002580989,0.2297671,0.00006894446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954404,0.001263615,0.0001440436,0.0002500298,0.00006720491,0.00002403194,0.000002181516,0.000003157286,0.002805285],"genre_scores_gemma":[0.9948109,0.001745464,0.0003966756,0.0001476172,0.0007201887,0.000001514273,0.000006275702,0.000006363122,0.002164963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2285013,"threshold_uncertainty_score":0.949477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087019183030389,"score_gpt":0.2323643742059643,"score_spread":0.2214941823756604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}