{"id":"W2072764114","doi":"10.1074/jbc.m210470200","title":"The Low Viral Production in Trophoblastic Cells Is Due to a High Endocytic Internalization of the Human Immunodeficiency Virus Type 1 and Can Be Overcome by the Pro-inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-1","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Biology; Virology; Vesicular stomatitis virus; Virus; Tumor necrosis factor alpha; Viral entry; Permissiveness; Viral shedding; Provirus; Viral replication; Trophoblast; Immunology; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003437127,0.000141562,0.0002547959,0.00002042134,0.0001619184,0.00002407886,0.0002386052,0.00009945621,0.00003837607],"category_scores_gemma":[0.0004198162,0.00006230542,0.00005675987,0.0001179878,0.000353879,0.00003972967,0.00007472876,0.0002925107,8.108312e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006060818,"about_ca_system_score_gemma":0.00004529998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003847119,"about_ca_topic_score_gemma":0.000005516961,"domain_scores_codex":[0.9988677,0.0002469929,0.0004655297,0.0001995298,0.00005423057,0.00016603],"domain_scores_gemma":[0.9991454,0.0001048144,0.0003975173,0.0002049572,0.000130041,0.00001721242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009656028,0.00004273931,0.008501392,0.00003819557,0.00003523645,0.000002246293,0.0004204399,0.000003178019,0.9905794,0.00002445527,0.0001271961,0.000128994],"study_design_scores_gemma":[0.0003495685,0.0002020514,0.0197951,0.0001498378,0.00001512528,0.0003434347,0.0002136153,2.954349e-7,0.9780446,0.000231209,0.0005759284,0.00007926449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952829,0.003882224,0.000008879048,0.0001981572,0.0003753584,0.0002031394,0.00001782474,0.00000354475,0.00002791307],"genre_scores_gemma":[0.9995015,0.000123712,0.000003072166,0.00004794996,0.0000310458,0.000006611952,0.000001431648,0.000005690665,0.0002789305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0125348,"threshold_uncertainty_score":0.2540741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159513887872611,"score_gpt":0.224024151477251,"score_spread":0.2124290125985249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}