{"id":"W2072764114","doi":"10.1074/jbc.m210470200","title":"The Low Viral Production in Trophoblastic Cells Is Due to a High Endocytic Internalization of the Human Immunodeficiency Virus Type 1 and Can Be Overcome by the Pro-inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-1","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Biology; Virology; Vesicular stomatitis virus; Virus; Tumor necrosis factor alpha; Viral entry; Permissiveness; Viral shedding; Provirus; Viral replication; Trophoblast; Immunology; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666928,0.000285681,0.0002684414,0.000176094,0.000154937,0.000541073,0.000162007,0.0002428357,0.001201474],"category_scores_gemma":[0.0002702116,0.000178851,0.0001868492,0.0001368028,0.0002998661,0.0002548409,0.0003364753,0.0005964573,0.0005549497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453318,"about_ca_system_score_gemma":0.0001886173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823989,"about_ca_topic_score_gemma":0.0004595897,"domain_scores_codex":[0.9997907,0.00006041933,0.00002402469,0.00004027958,0.00005502712,0.00002939981],"domain_scores_gemma":[0.9997913,0.00006642006,0.00004407385,0.00004240137,0.00002452347,0.00003127263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005220667,0.000004533413,0.0006611274,0.00003189023,0.000003275919,0.00004953734,0.0000220507,0.00001123266,0.9984142,0.00008837994,0.00001192531,0.0006495364],"study_design_scores_gemma":[0.000005911284,0.0001691053,0.01270499,0.00001225439,0.00001442532,0.0009821573,0.00007363495,0.0002668707,0.9817935,0.00009402313,0.003878821,0.000004238834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810647,0.004883308,0.0107201,0.0001393442,0.00002783301,0.00003322317,0.0005163715,0.000103338,0.002511636],"genre_scores_gemma":[0.9917096,0.001671659,0.004072383,0.00003422664,0.00001056513,0.00005232025,0.0006171074,0.00002603234,0.001806204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201474,"threshold_uncertainty_score":0.00401938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159513887872611,"score_gpt":0.224024151477251,"score_spread":0.2124290125985249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}