{"id":"W2072772509","doi":"10.1038/cddis.2011.105","title":"Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Wnt signaling pathway; Biology; Blastema; Wilms' tumor; Cellular differentiation; Stromal cell; Gene; Laser capture microdissection; Cell biology; Gene expression; Gene expression profiling; Microarray analysis techniques; Signal transduction; Microarray; Cancer research; Genetics; Regeneration (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307434,0.0001540286,0.0001579623,0.00006467519,0.00009483469,0.00002824337,0.0001087492,0.00008400816,0.00001721718],"category_scores_gemma":[0.00002995098,0.0001034373,0.0001177153,0.0001251034,0.00003325442,0.000005554998,0.00005639993,0.00005552081,0.000001000416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004844979,"about_ca_system_score_gemma":0.0001487389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006423036,"about_ca_topic_score_gemma":0.000005612311,"domain_scores_codex":[0.9990633,0.00006711866,0.0002060181,0.0003656637,0.00008753087,0.0002104177],"domain_scores_gemma":[0.9991186,0.00001134542,0.0000728418,0.0001868941,0.00002597527,0.0005843831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001076684,0.0001340064,0.02248934,0.0001394507,0.00008744549,0.00007488522,0.0005460162,0.0002368913,0.972672,0.000009494966,0.002345457,0.000188307],"study_design_scores_gemma":[0.002104279,0.0003870237,0.006181011,0.00006774251,0.0007280934,0.000007992161,0.0003530224,0.0002607166,0.9872829,0.0004928953,0.00169293,0.0004413711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951414,0.003501374,0.0005849717,0.0001006839,0.00005208819,0.000330239,0.00009798068,0.000005569202,0.0001856944],"genre_scores_gemma":[0.997607,0.000163736,0.0005233768,0.0006944764,0.00007984244,0.00003450705,0.0002398335,0.00001257573,0.0006446413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01630833,"threshold_uncertainty_score":0.4218051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100472994036746,"score_gpt":0.2197015024217446,"score_spread":0.2086967724813771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}