{"id":"W2072778238","doi":"10.1002/cmdc.200600071","title":"Synthesis of Libraries of 16β‐Aminopropyl Estradiol Derivatives for Targeting Two Key Steroidogenic Enzymes","year":2006,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Steroid; Acylation; Nucleophile; Phenol; Enzyme; Phenols; Chloride; Linker; Combinatorial chemistry; Organic chemistry; Stereochemistry; Hormone; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002207823,0.0007965994,0.0006571956,0.0004989148,0.0001402896,0.0003431534,0.0003698429,0.0002938025,0.002816533],"category_scores_gemma":[0.0002791723,0.000320616,0.0002891617,0.0005948214,0.0001482801,0.0002957399,0.000331332,0.0004335683,0.001109527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812358,"about_ca_system_score_gemma":0.0003884531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002502819,"about_ca_topic_score_gemma":0.0006183962,"domain_scores_codex":[0.9997858,0.00003454059,0.00001865203,0.00003627295,0.00007476418,0.00005000289],"domain_scores_gemma":[0.9998223,0.00002510763,0.00003780333,0.00002507197,0.00003376391,0.00005597321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002669565,0.00008267222,0.0001749664,0.00009101954,0.00002105872,0.0001428813,0.0000242575,0.0005773049,0.9847936,0.0002247356,0.000171513,0.013429],"study_design_scores_gemma":[0.00009310468,0.00127779,0.000915089,0.000008496285,0.00006218639,0.000397561,0.00001386143,0.0007044871,0.9878002,0.00006825059,0.008644692,0.0000142681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511979,0.003989572,0.03215272,0.0001575751,0.00009519618,0.0006176622,0.002571517,0.0007538639,0.008464018],"genre_scores_gemma":[0.9188408,0.004999892,0.05028214,0.0001983097,0.00005193693,0.0005158883,0.006562504,0.0001631517,0.01838535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002816533,"threshold_uncertainty_score":0.009422243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008939965417464207,"score_gpt":0.2234413859612193,"score_spread":0.2145014205437551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}