{"id":"W2072807060","doi":"10.2353/ajpath.2008.070875","title":"Retrovirally Mediated Overexpression of Glycosaminoglycan-Deficient Biglycan in Arterial Smooth Muscle Cells Induces Tropoelastin Synthesis and Elastic Fiber Formation in Vitro and in Neointimae after Vascular Injury","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Biglycan; Tropoelastin; In vitro; Vascular smooth muscle; Glycosaminoglycan; Elastin; Cell biology; Chemistry; Proteoglycan; Biophysics; Smooth muscle; Anatomy; Extracellular matrix; Pathology; Biochemistry; Medicine; Biology; Internal medicine; Decorin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003672575,0.0005415951,0.0003261372,0.000529083,0.0003442478,0.0005790446,0.0004974074,0.0005662237,0.001521284],"category_scores_gemma":[0.0001996783,0.0004383405,0.0004376712,0.0004379185,0.0004261055,0.0003695099,0.0002860795,0.001270113,0.0007581266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005873308,"about_ca_system_score_gemma":0.000346826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085676,"about_ca_topic_score_gemma":0.001668848,"domain_scores_codex":[0.9996378,0.00006173224,0.00004254676,0.00005217872,0.00008884511,0.000116742],"domain_scores_gemma":[0.999588,0.0001132835,0.00006856288,0.00007545932,0.00002868147,0.0001260758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340236,0.00004964147,0.00007837334,0.00001151926,0.000006023497,0.00004934213,0.00001818155,0.00004921388,0.999034,0.0002394976,0.0000283388,0.0003018228],"study_design_scores_gemma":[0.00002822952,0.000198954,0.001395551,0.000002686546,0.00002054382,0.0001101038,0.00002961415,0.0009543395,0.9960911,0.00005483447,0.001109599,0.000004391402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933941,0.0006363334,0.003478637,0.0001287514,0.0001301857,0.00005984179,0.0005445232,0.0001129395,0.001514748],"genre_scores_gemma":[0.9874676,0.0004597542,0.004696741,0.00008929331,0.00003882683,0.00007087475,0.001285522,0.0000483702,0.005843021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001521284,"threshold_uncertainty_score":0.005089223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006783295916840748,"score_gpt":0.234632969147665,"score_spread":0.2278496732308242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}