{"id":"W2072807060","doi":"10.2353/ajpath.2008.070875","title":"Retrovirally Mediated Overexpression of Glycosaminoglycan-Deficient Biglycan in Arterial Smooth Muscle Cells Induces Tropoelastin Synthesis and Elastic Fiber Formation in Vitro and in Neointimae after Vascular Injury","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Biglycan; Tropoelastin; In vitro; Vascular smooth muscle; Glycosaminoglycan; Elastin; Cell biology; Chemistry; Proteoglycan; Biophysics; Smooth muscle; Anatomy; Extracellular matrix; Pathology; Biochemistry; Medicine; Biology; Internal medicine; Decorin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045829,0.0001278762,0.0003667249,0.0004253572,0.00001692924,0.000005603695,0.00009716561,0.00008931883,0.00001573096],"category_scores_gemma":[0.0003888422,0.0001173953,0.00004396207,0.0002277098,0.0003836812,0.00001865796,0.0000878322,0.0001939381,6.346531e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003623802,"about_ca_system_score_gemma":0.00007006427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009037176,"about_ca_topic_score_gemma":0.00006767359,"domain_scores_codex":[0.9985616,0.0003884747,0.0004572487,0.0002083576,0.0001550425,0.0002292262],"domain_scores_gemma":[0.9993728,0.0001030122,0.0002754895,0.0001192971,0.00006941761,0.0000599749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001900694,0.0001135999,0.003474572,0.00001619602,0.000006927366,0.0001498171,0.000564626,0.0000465321,0.9792085,2.642649e-7,0.00000550067,0.01451281],"study_design_scores_gemma":[0.002356911,0.002568471,0.5477141,0.0001497148,0.00001465915,0.0001705506,0.0009265525,0.0002075143,0.4455093,0.00002405824,0.0001211879,0.000236888],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993069,0.0003630616,0.0001114612,0.00004506058,0.00002588496,0.0001135778,0.00001765071,0.000001045358,0.0000154021],"genre_scores_gemma":[0.9989809,0.0004525825,0.000486773,0.00002517747,0.00002276801,0.00001189664,0.000005426415,0.00001243415,0.000001995651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5442396,"threshold_uncertainty_score":0.4787241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006783295916840748,"score_gpt":0.234632969147665,"score_spread":0.2278496732308242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}