{"id":"W2072846173","doi":"10.1016/s1672-0229(08)60032-7","title":"Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin","year":2009,"lang":"en","type":"article","venue":"Genomics Proteomics & Bioinformatics","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; York University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Hemagglutinin (influenza); Phylogenetic tree; Influenza A virus subtype H5N1; Biology; Antigenic drift; Virus; Virology; Positive selection; Epitope; Selection (genetic algorithm); Host (biology); Antigenic shift; Influenza A virus; Glycoprotein; Antigenic variation; Evolutionary biology; Genetics; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005822568,0.0001810128,0.0003632022,0.0002498828,0.0001407765,0.0000143546,0.0001831778,0.0001291564,0.00001164572],"category_scores_gemma":[0.0003576653,0.0001295153,0.0001264057,0.0003838706,0.0001632275,0.000108241,0.00007233023,0.0003423286,0.00002252623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003026675,"about_ca_system_score_gemma":0.0003467571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003990652,"about_ca_topic_score_gemma":0.000003034406,"domain_scores_codex":[0.998473,0.00004297769,0.0006484825,0.0001186711,0.0004072012,0.0003096901],"domain_scores_gemma":[0.9985804,0.0000887521,0.0004409386,0.0003455066,0.0004804676,0.00006391616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003940601,0.0007714596,0.002221526,0.0007701488,0.0008988231,0.000001238832,0.01630734,0.003594493,0.8517331,0.0904336,0.001413249,0.02791439],"study_design_scores_gemma":[0.002044397,0.003682451,0.02229671,0.0003812631,0.0002797382,0.00003596881,0.004343397,0.1054416,0.8505138,0.008102134,0.002544035,0.000334484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618396,0.0007186983,0.003711223,0.001352409,0.00005075485,0.003960887,0.0001786626,0.00005519603,0.02813255],"genre_scores_gemma":[0.97282,0.0001307385,0.02645677,0.0003009808,0.00007198235,0.00002714273,0.00001334713,0.00001515859,0.0001638433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1018471,"threshold_uncertainty_score":0.5281479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814241463968079,"score_gpt":0.2826438557032382,"score_spread":0.2645014410635574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}