{"id":"W2072860434","doi":"10.1016/j.semcancer.2015.03.001","title":"Broad targeting of resistance to apoptosis in cancer","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":846,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Terry Fox Foundation; National Institutes of Health; Ministry of Science and Technology, Taiwan; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institute on Minority Health and Health Disparities; National Center for Research Resources; Taipei Medical University; National Science Council; European Cooperation in Science and Technology; United Soybean Board; Barbara Ann Karmanos Cancer Institute; Al Jalila Foundation; Jackson State University","keywords":"Necroptosis; Apoptosis; Cancer; Cancer research; Cancer cell; Programmed cell death; Signal transduction; Autophagy; XIAP; Biology; Cell biology; Caspase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003041504,0.0006903605,0.001016714,0.001879332,0.0002713993,0.0007055539,0.0006791811,0.0008628339,0.002730557],"category_scores_gemma":[0.0002823082,0.0002173931,0.0003477757,0.001346319,0.0003876132,0.000967385,0.0006468827,0.001444541,0.001989395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006588208,"about_ca_system_score_gemma":0.0005720303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000506417,"about_ca_topic_score_gemma":0.0008970884,"domain_scores_codex":[0.9998851,0.00001689167,0.00001427822,0.00002203501,0.00004598157,0.00001564349],"domain_scores_gemma":[0.99991,0.00002860285,0.0000144093,0.000005001394,0.00002662522,0.00001541237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007096054,0.00009598141,0.0001367885,0.013885,0.00006224022,0.0003893746,0.00006901471,0.0005144928,0.008760365,0.008217606,0.02602744,0.9417706],"study_design_scores_gemma":[0.00001657391,0.0001012843,0.000538135,0.00123554,0.00004452267,0.001670294,0.0000338158,0.00009432623,0.001675913,0.001984512,0.992589,0.00001595919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003422026,0.9963605,0.0003753607,0.0002593339,0.0001939759,0.00001004361,0.00002706079,0.00002124224,0.002410331],"genre_scores_gemma":[0.001819509,0.9963335,0.0003688996,0.0002137459,0.000103625,0.00001395324,0.00004660302,0.000002991779,0.001097216],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002730557,"threshold_uncertainty_score":0.009134591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406433358245574,"score_gpt":0.3697603079606936,"score_spread":0.3356959743782379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}