{"id":"W2072903117","doi":"10.1160/th08-04-0200","title":"Propagating factor IX-producing hepatocytes for haemophilia B therapy","year":2008,"lang":"en","type":"letter","venue":"Thrombosis and Haemostasis","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Factor IX; Haemophilia B; Medicine; Haemophilia; In vivo; Clotting factor; Immunology; Haemophilia A; Immune system; Internal medicine; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004523316,0.000259224,0.0002501658,0.000333058,0.0001455229,0.0006008006,0.0001688487,0.0003196284,0.003991852],"category_scores_gemma":[0.0002395308,0.0001274903,0.0002023414,0.0001875169,0.0001617923,0.0002649788,0.0003500701,0.0006736889,0.001764663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001689096,"about_ca_system_score_gemma":0.0001664786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003387368,"about_ca_topic_score_gemma":0.000553078,"domain_scores_codex":[0.9998821,0.00003202135,0.000009808992,0.0000116762,0.00004660653,0.00001775452],"domain_scores_gemma":[0.999911,0.0000183754,0.00001512917,0.00001914444,0.00001871013,0.00001763899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002902065,0.0002451681,0.0004820904,0.0002343799,0.00002402087,0.0003884169,0.0001095998,0.0004635988,0.9451426,0.001729838,0.00254145,0.04834865],"study_design_scores_gemma":[0.0002976722,0.001669155,0.002428983,0.00008679376,0.0000950981,0.001749426,0.0001062364,0.003616703,0.9238338,0.0006837185,0.06541238,0.00001987817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7882292,0.02800342,0.1249044,0.002315267,0.001823996,0.001360795,0.001359125,0.001512518,0.05049123],"genre_scores_gemma":[0.9412434,0.01058806,0.03303606,0.0003751257,0.0002010566,0.000325408,0.0009317055,0.0001251385,0.01317402],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003991852,"threshold_uncertainty_score":0.01335406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1158792303126928,"score_gpt":0.346282927099672,"score_spread":0.2304036967869792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}