{"id":"W2072903143","doi":"10.1158/0008-5472.can-07-3046","title":"The Estrogen Receptor Pathway in Rhabdomyosarcoma: A Role for Estrogen Receptor-β in Proliferation and Response to the Antiestrogen 4′OH-Tamoxifen","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Antiestrogen; Estrogen receptor; Tamoxifen; Cancer research; Biology; Estrogen; Estrogen receptor alpha; Signal transduction; Cell growth; Rhabdomyosarcoma; Internal medicine; Progesterone receptor; Endocrinology; Medicine; Sarcoma; Cancer; Pathology; Cell biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166172,0.0002393523,0.0003754263,0.0002470253,0.0001184308,0.0001984576,0.0001257562,0.0003177102,0.001068877],"category_scores_gemma":[0.0001003915,0.0001399213,0.0002840355,0.0001500814,0.0001616674,0.0001813963,0.0001032901,0.0003232546,0.0003815768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002027552,"about_ca_system_score_gemma":0.0001256455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005176873,"about_ca_topic_score_gemma":0.0006346793,"domain_scores_codex":[0.9999169,0.00001802022,0.00001044191,0.00001265611,0.00001905628,0.00002282227],"domain_scores_gemma":[0.9999561,0.000009258048,0.000009938243,0.000005901004,0.000008497501,0.00001032189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00072826,0.0000576361,0.001310783,0.00006837944,0.0000104812,0.0001649362,0.00003222462,0.00006161617,0.9939005,0.00003276376,0.00006944527,0.003562933],"study_design_scores_gemma":[0.0001712354,0.002904865,0.1233982,0.00002661862,0.00009869214,0.001963844,0.0002644841,0.000886568,0.8617069,0.0001720813,0.008389268,0.00001719152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883702,0.009210592,0.0006326683,0.000193796,0.00003815011,0.00003476268,0.0003673059,0.00003168322,0.00112081],"genre_scores_gemma":[0.9910053,0.005131,0.000768356,0.0001423219,0.00002489044,0.00007343575,0.0007353194,0.000009677859,0.002109678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068877,"threshold_uncertainty_score":0.003575802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06575741624045725,"score_gpt":0.3727053115425016,"score_spread":0.3069478953020444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}