{"id":"W2072919270","doi":"10.1038/sj.mt.6300147","title":"Anti-CD25 Targeted Killing of Bicistronically Transduced Cells: A Novel Safety Mechanism Against Retroviral Genotoxicity","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Immunotoxin; Antibody; Genetic enhancement; Cancer research; Leukemia; Viral vector; Biology; Immunology; Virology; Monoclonal antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003099488,0.000506009,0.0002921784,0.0002720369,0.0002803155,0.0005726893,0.0004280732,0.000485706,0.0008427768],"category_scores_gemma":[0.0001466902,0.0001675794,0.0002850553,0.0001235868,0.0004476276,0.0003849675,0.000295111,0.0008117378,0.0002446253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005110491,"about_ca_system_score_gemma":0.0002791862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003493608,"about_ca_topic_score_gemma":0.000473473,"domain_scores_codex":[0.9997852,0.00003324099,0.00001418946,0.00004687614,0.00006066826,0.00005980212],"domain_scores_gemma":[0.9999129,0.00001861514,0.00001890127,0.00002528301,0.00001317819,0.00001104602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009076959,0.00001507847,0.00007649582,0.00001905407,0.000004624366,0.00004305636,0.00001577917,0.0001470986,0.9964709,0.001148354,0.00004608721,0.001922721],"study_design_scores_gemma":[0.00001550247,0.0001380366,0.0003299839,0.000002412729,0.0000103708,0.0002005699,0.000009363013,0.001012066,0.9972245,0.0001362229,0.0009172953,0.000003766371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506375,0.001557401,0.04368427,0.0003333932,0.00006374394,0.00008458176,0.0001812546,0.0003898719,0.003068035],"genre_scores_gemma":[0.9928296,0.0002988918,0.005217526,0.00006592184,0.000008702343,0.00003369753,0.0000719907,0.000017904,0.001455772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008427768,"threshold_uncertainty_score":0.003707945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415798260756953,"score_gpt":0.2715725973761636,"score_spread":0.2574146147685941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}