{"id":"W2072921716","doi":"10.1002/cmdc.201100453","title":"Platinum(II) Phenanthroimidazoles for Targeting Telomeric G‐Quadruplexes","year":2011,"lang":"en","type":"article","venue":"ChemMedChem","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomere; G-quadruplex; Circular dichroism; DNA; Chemistry; Intramolecular force; Cytotoxic T cell; Fluorescence; Molecular biology; Cancer cell; Stereochemistry; Biology; Cancer; Cancer research; Biochemistry; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237419,0.0002318263,0.0001908878,0.00001989637,0.0001819369,0.00001141097,0.0002959521,0.0002025811,0.000146857],"category_scores_gemma":[0.0001389015,0.0002194022,0.0001544638,0.0000572634,0.000154694,0.000005474395,0.0001734964,0.00008454864,0.00001313184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001300837,"about_ca_system_score_gemma":0.00004659275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005928342,"about_ca_topic_score_gemma":0.000001289286,"domain_scores_codex":[0.9987987,0.00000680657,0.0002498257,0.0004302227,0.000101439,0.0004129698],"domain_scores_gemma":[0.999329,0.00001255948,0.0001180326,0.0003416189,0.00007958875,0.000119147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008364135,0.00009047477,0.000609194,0.0000564732,0.00005093979,0.0000014741,0.000282912,6.182108e-7,0.9825951,0.00004868117,0.01401175,0.002168692],"study_design_scores_gemma":[0.0005738195,0.00009903414,0.0001719791,0.0000127031,0.00002276176,0.000008822564,0.0003468024,0.00002764287,0.9636262,0.0003217208,0.03448357,0.0003049402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820343,0.0005602509,0.0007005825,0.00007639812,0.0001634966,0.0001702315,0.00002547945,0.00005191557,0.01621734],"genre_scores_gemma":[0.9889314,0.00007033967,0.008436784,0.0002002025,0.0005240309,0.00008042793,0.0002370098,0.00005389121,0.001465895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02047182,"threshold_uncertainty_score":0.8946961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02320821153945999,"score_gpt":0.2384598970519552,"score_spread":0.2152516855124953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}