{"id":"W2072921716","doi":"10.1002/cmdc.201100453","title":"Platinum(II) Phenanthroimidazoles for Targeting Telomeric G‐Quadruplexes","year":2011,"lang":"en","type":"article","venue":"ChemMedChem","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Telomerase; Telomere; G-quadruplex; Circular dichroism; DNA; Chemistry; Intramolecular force; Cytotoxic T cell; Fluorescence; Molecular biology; Cancer cell; Stereochemistry; Biology; Cancer; Cancer research; Biochemistry; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608313,0.0002546165,0.0002175137,0.000136945,0.0001196071,0.0001758856,0.0003391162,0.0002904119,0.000436784],"category_scores_gemma":[0.0002470481,0.0001536758,0.00008700394,0.0001448106,0.0001384669,0.0001350162,0.0001278127,0.0002896236,0.0001498788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003345531,"about_ca_system_score_gemma":0.0002002921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195475,"about_ca_topic_score_gemma":0.001792815,"domain_scores_codex":[0.9998726,0.00002711898,0.00001054546,0.00002330792,0.00004918689,0.00001731549],"domain_scores_gemma":[0.9999341,0.0000108452,0.00002134601,0.000006686604,0.000009971423,0.0000170866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001179649,0.00006615513,0.000214557,0.00006732662,0.00000726555,0.00009601293,0.00002033653,0.001364432,0.9934417,0.0002436658,0.0001013296,0.004259272],"study_design_scores_gemma":[0.00007162595,0.000601412,0.0006802492,0.000003650511,0.00001516916,0.000287905,0.000006809772,0.002425838,0.9932783,0.00003866647,0.002584888,0.000005457635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838138,0.002703317,0.01082829,0.0001764812,0.00003021789,0.0001407308,0.0001061611,0.000186006,0.002015014],"genre_scores_gemma":[0.989611,0.0008976849,0.00807773,0.00004446917,0.000006392379,0.00003801872,0.0001219669,0.00001143202,0.0011913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005195475,"threshold_uncertainty_score":0.00242734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02320821153945999,"score_gpt":0.2384598970519552,"score_spread":0.2152516855124953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}