{"id":"W2072922828","doi":"10.1111/j.1745-7254.2005.00165.x","title":"Molecular basis of ataxia telangiectasia and related diseases","year":2005,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Ataxia-telangiectasia; Rad50; Kinase; Genome instability; Biology; DNA repair; DNA damage; Gene; Ku70; Genetics; Cell biology; DNA-PKcs; Phosphorylation; Protein subunit; DNA; Cancer research; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003604771,0.0008747114,0.001492204,0.001226873,0.0003035412,0.0008032072,0.001153125,0.001079988,0.002539155],"category_scores_gemma":[0.0002790922,0.000303708,0.0003320109,0.001270254,0.0005041783,0.0008238236,0.000401057,0.001630362,0.002130814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006971011,"about_ca_system_score_gemma":0.0009551916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007399617,"about_ca_topic_score_gemma":0.001149143,"domain_scores_codex":[0.9998878,0.00001915748,0.00001539687,0.00001838018,0.00004586393,0.00001339884],"domain_scores_gemma":[0.9999036,0.00003252533,0.00001899269,0.000005424352,0.00002769792,0.00001189769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001811816,0.0001526883,0.0002190834,0.008093046,0.00009812503,0.0009454107,0.0000470262,0.0005899974,0.01041642,0.006474974,0.02815028,0.9446318],"study_design_scores_gemma":[0.00007483284,0.00008274831,0.001014773,0.001044298,0.0001533772,0.004075991,0.00004612256,0.0001509324,0.002295893,0.003824403,0.9872183,0.00001823804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002278388,0.9974079,0.0004219234,0.0003009869,0.0002313511,0.000007627974,0.0000183644,0.00001672112,0.00136731],"genre_scores_gemma":[0.00129572,0.9967906,0.0005235702,0.0001578392,0.0001900356,0.0000122335,0.00003309604,0.000001066801,0.0009958636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002539155,"threshold_uncertainty_score":0.008494318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533186005983471,"score_gpt":0.3402506861886863,"score_spread":0.3149188261288516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}